产地 | 上海 |
品牌 | OminimAbs |
保存条件 | |
货号 | OM641708 |
用途 | 实验研究 |
应用范围 | 科研实验 |
抗原来源 | 电询 |
保质期 | 2年 |
抗体名 | 电询 |
是否单克隆 | 否 |
克隆性 | 否 |
靶点 | 电询 |
适应物种 | 电询 |
形态 | 电询 |
宿主 | 电询 |
标记物 | 电询 |
包装规格 | 毫升 |
亚型 | 电询 |
标识物 | 电询 |
浓度 | 电询% |
免疫原 | 电询 |
是否进口 | 否 |
Product Profile
Product Name
claudin-5 Antibody (H-52)
Antibody Type
Primary Antibodies
Modification
Notes
The claudin superfamily consists of many
structurally related proteins in humans. These proteins are important
structural and functional components of tight junctions in paracellular
transport. Claudins are located in both epithelial and endothelial cells in
all tight junction-bearing tissues. Three classes of proteins are known to
localize to tight junctions, including the claudins, Occludin and Junction
adhesion molecule. Claudins, which consist of four transmembrane domains and
two extracellular loops make up tight junction strands. Claudin expression is
highly restricted to specfic regions of different tissues and may have an
important role in transcellular transport through tight junctions. Claudin-5
is expressed in the endothelial junctions of the rat liver and in junctions
of acinar cells of the pancreas. Human Claudin-5 is abundantly expressed in
adult lung, heart and skeletal muscle and is deleted in patients with
velocardiofacial syndrone, which is characterized by cleft palate, facial
dysmorphology and conotruncal heart defects.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Applications
WBIPIFELISA
recommended for detection of claudin-5 of
mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with
additional species, including canine, bovine and porcine:
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Alternative
Names
epitope corresponding to amino acids
167-218 mapping at the C-terminus of claudin-5 of human origin
Tissue
Specificity
epitope corresponding to amino acids
167-218 mapping at the C-terminus of claudin-5 of human origin
Database Links
Entrez Gene
7122
Application
·
Application
Western blot analysis of claudin-5 expression in non-transfected: (A) and human claudin-5 transfected: (B) 293T whole cell lysates.
Application Notes |
recommended for detection of claudin-5 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine, bovine and porcine: |
Additional Information
Form |
Liquid |
Storage Instructions |
For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20oC or below. Avoid multiple freeze-thaw cycles. |
Storage Buffer |
phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |