Product Name

Claudin 5 (phospho Tyr217) Antibody

Antibody Type

Primary Antibodies

Product description

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome.1) Sirotkin H., Genomics 42:245-251(1997).

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Immunogen

Claudin 5 (phospho Tyr217) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 217 (K-K-N-Y (p)-V) derived from Human Claudin 5.

Clonality

Polyclonal

Isotype

IgG

Host Species

Rabbit

Tested Applications

IHC

IHC:1:50~1:200
Notes:Optimal dilutions/concentrations should be determined by the researcher.

Species Reactivity

HumanMouseRat

Concentration

1 mg/ml

Purification

Affinity purified

Gene Symbol

CLDN5

Alternative Names

CLD5
CLDN5
TMDVCF

Molecular Weight(MW)

23 kDa

Tissue Specificity

The antibody detects endogenous levels of Claudin 5 only when phosphorylated at tyrosine 217.

Entrez Gene

7122

Protein Accession

NP_001124333.1

Application Notes

IHC:1:50~1:200
Notes:Optimal dilutions/concentrations should be determined by the researcher.

Form

Liquid

Storage Instructions

Store antibody at -20?C for up to one year.

Storage Buffer

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.