产地 | 上海 |
品牌 | OminimAbs |
保存条件 | |
货号 | OM641714 |
用途 | 实验研究 |
应用范围 | 科研实验 |
抗原来源 | 电询 |
保质期 | 2年 |
抗体名 | 电询 |
是否单克隆 | 否 |
克隆性 | 否 |
靶点 | 电询 |
适应物种 | 电询 |
形态 | 电询 |
宿主 | 电询 |
标记物 | 电询 |
包装规格 | 毫升 |
亚型 | 电询 |
标识物 | 电询 |
浓度 | 电询% |
免疫原 | 电询 |
是否进口 | 否 |
Product Profile
Product Name
Anti-TLR4 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAIHC
IHC:1:200-1:1000
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
TLR4
Gene Synonyms
TOLL
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Gene Full Name
toll like receptor 4
Gene Summary
The protein encoded by this gene is a
member of the Toll-like receptor (TLR) family which plays a fundamental role
in pathogen recognition and activation of innate immunity. TLRs are highly
conserved from Drosophila to humans and share structural and functional
similarities. They recognize pathogen-associated molecular patterns that are
expressed on infectious agents, and mediate the production of cytokines
necessary for the development of effective immunity. The various TLRs exhibit
different patterns of expression. In silico studies have found a particularly
strong binding of surface TLR4 with the spike protein of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
Coronavirus disease-2019 (COVID-19). This receptor has also been implicated
in signal transduction events induced by lipopolysaccharide (LPS) found in
most gram-negative bacteria. Mutations in this gene have been associated with
differences in LPS responsiveness, and with susceptibility to age-related
macular degeneration. Multiple transcript variants encoding different
isoforms have been found for this gene. [provided by RefSeq, Aug 2020]
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Source
Rabbit
Cellular
Localizatio
Plasma membrane; Endosome
Application
CD284
TLR-4
ARMD10
·
IHC
Immunohistochemical analysis of paraffin-embedded rectal cancer tissues using TLR4 antibody with DAB staining
·
IHC
Immunohistochemical analysis of paraffin-embedded ovarian cancer tissues using TLR4 antibody with DAB staining.
Application Notes |
IHC:1:200-1:1000 |
Additional Information
Form |
Liquid |
Storage Instruction |
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
Storage Buffer |
Purified antibody in PBS with 0.05% sodium azide. |