产地 | 上海 |
品牌 | OminimAbs |
保存条件 | |
货号 | OM641708 |
用途 | 实验研究 |
应用范围 | 科研实验 |
抗原来源 | 电询 |
保质期 | 2年 |
抗体名 | 电询 |
是否单克隆 | 否 |
克隆性 | 否 |
靶点 | 电询 |
适应物种 | 电询 |
形态 | 电询 |
宿主 | 电询 |
标记物 | 电询 |
包装规格 | 毫升 |
亚型 | 电询 |
标识物 | 电询 |
浓度 | 电询% |
免疫原 | 电询 |
是否进口 | 否 |
Product Profile
Product Name
Anti-RPA1 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAIHC
IHC:1:200-1:2000
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
RPA1
Gene Synonyms
HSSB
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Gene Full Name
replication protein A1
Gene Summary
This gene encodes the largest subunit of
the heterotrimeric Replication Protein A (RPA) complex, which binds to
single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an
important role in DNA metabolism, being involved in DNA replication, repair,
recombination, telomere maintenance, and co-ordinating the cellular response
to DNA damage through activation of the ataxia telangiectasia and
Rad3-related protein (ATR) kinase. The nucleoprotein complex protects the
single-stranded DNA from nucleases, prevents formation of secondary
structures that would interfere with repair, and co-ordinates the recruitment
and departure of different genome maintenance factors. This subunit contains
four oligonucleotide/oligosaccharide-binding (OB) domains, though the
majority of ssDNA binding occurs in two of these domains. The heterotrimeric
complex has two different modes of ssDNA binding, a low-affinity and
high-affinity mode, determined by which ssDNA binding domains are utilized.
The different binding modes differ in the length of DNA bound and in the
proteins with which it interacts, thereby playing a role in regulating
different genomic maintenance pathways. [provided by RefSeq, Sep 2017]
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Molecular
Weight(MW)
68KD
Cellular
Localizatio
Nucleus
Application
RF-A
RP-A
REPA1
RPA70
MST075
PFBMFT6
·
IHC
Immunohistochemical analysis of paraffin-embedded renal carcinoma tissues using RPA1 antibody with DAB staining.
·
IHC
Immunohistochemical analysis of paraffin-embedded breast cancer tissues using RPA1 antibody with DAB staining.
Application Notes |
IHC:1:200-1:2000 |
Additional Information
Form |
Liquid |
Storage Instruction |
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
Storage Buffer |
Purified antibody in PBS with 0.05% sodium azide. |