产地 | 上海 |
品牌 | OminimAbs |
保存条件 | |
货号 | OM641708 |
用途 | 实验研究 |
应用范围 | 科研实验 |
抗原来源 | 电询 |
保质期 | 2年 |
抗体名 | 电询 |
是否单克隆 | 否 |
克隆性 | 否 |
靶点 | 电询 |
适应物种 | 电询 |
形态 | 电询 |
宿主 | 电询 |
标记物 | 电询 |
包装规格 | 毫升 |
亚型 | 电询 |
标识物 | 电询 |
浓度 | 电询% |
免疫原 | 电询 |
是否进口 | 否 |
Product Profile
Product Name
Anti-RPA2 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAWB
WB:1:200-1:2000
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
RPA2
Gene Synonyms
REPA2
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Gene Full Name
replication protein A2
Gene Summary
This gene encodes a subunit of the
heterotrimeric Replication Protein A (RPA) complex, which binds to
single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an
important role in DNA metabolism, being involved in DNA replication, repair, recombination,
telomere maintenance, and co-ordinating the cellular response to DNA damage
through activation of the ataxia telangiectasia and Rad3-related protein
(ATR) kinase. The RPA complex protects single-stranded DNA from nucleases,
prevents formation of secondary structures that would interfere with repair,
and co-ordinates the recruitment and departure of different genome
maintenance factors. The heterotrimeric complex has two different modes of
ssDNA binding, a low-affinity and high-affinity mode, determined by which
oligonucleotide/oligosaccharide-binding (OB) domains of the complex are
utilized, and differing in the length of DNA bound. This subunit contains a
single OB domain that participates in high-affinity DNA binding and also
contains a winged helix domain at its carboxy terminus, which interacts with
many genome maintenance protein. Post-translational modifications of the RPA
complex also plays a role in co-ordinating different damage response
pathways. [provided by RefSeq, Sep 2017]
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Molecular
Weight(MW)
29KD,38KD
Cellular
Localizatio
Nucleus
Application
RPA32
RP-A p32
RP-A p34
·
WB
Western blot analysis using RPA2 antibody against Hek293(1) cell lysate.
Application Notes |
WB:1:200-1:2000 |
Additional Information
Form |
Liquid |
Storage Instruction |
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
Storage Buffer |
Purified antibody in PBS with 0.05% sodium azide. |