|
- 品牌：OminimAbs
- 产地：上海
- 型号：毫升
- 货号：OM641708
- 发布日期： 2024-09-11
- 更新日期： 2024-10-09
| 产地 | 上海 |
| 品牌 | OminimAbs |
| 保存条件 | |
| 货号 | OM641708 |
| 用途 | 实验研究 |
| 应用范围 | 科研实验 |
| 抗原来源 | 电询 |
| 保质期 | 2年 |
| 抗体名 | 电询 |
| 是否单克隆 | 否 |
| 克隆性 | 否 |
| 靶点 | 电询 |
| 适应物种 | 电询 |
| 形态 | 电询 |
| 宿主 | 电询 |
| 标记物 | 电询 |
| 包装规格 | 毫升 |
| 亚型 | 电询 |
| 标识物 | 电询 |
| 浓度 | 电询% |
| 免疫原 | 电询 |
| 是否进口 | 否 |
Product Profile
Product Name
Anti-MAP3K5 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHC
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
MAP3K5
Gene Synonyms
ASK1
MEKK5
MAPKKK5
Gene Full Name
mitogen-activated protein kinase kinase
kinase 5
Gene Summary
Mitogen-activated protein kinase (MAPK)
signaling cascades include MAPK or extracellular signal-regulated kinase
(ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK).
MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase,
MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling
cascades are highly conserved, and homologs exist in yeast, Drosophila, and
mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase
subdomains. Northern blot analysis shows that MAPKKK5 transcript is
abundantly expressed in human heart and pancreas. The MAPKKK5 protein
phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and
activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase
(SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not
activate MAPK/ERK. [provided by RefSeq, Jul 2008]
More
Molecular
Weight(MW)
155KD
Cellular
Localizatio
Cytoplasm, Endoplasmic reticulum
Application
·
IHC
Immunohistochemical
analysis of paraffin-embedded lung cancer tissues using MAP3K5 antibody with
DAB staining.
·
IHC
Immunohistochemical
analysis of paraffin-embedded prostate cancer tissues using MAP3K5 antibody
with DAB staining.
·
ICC/IF
Immunofluorescence
analysis of Hela cells using MAP3K5 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-MAP3K5 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHC
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
MAP3K5
Gene Synonyms
ASK1
MEKK5
MAPKKK5
Gene Full Name
mitogen-activated protein kinase kinase
kinase 5
Gene Summary
Mitogen-activated protein kinase (MAPK)
signaling cascades include MAPK or extracellular signal-regulated kinase
(ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK).
MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase,
MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling
cascades are highly conserved, and homologs exist in yeast, Drosophila, and
mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase
subdomains. Northern blot analysis shows that MAPKKK5 transcript is
abundantly expressed in human heart and pancreas. The MAPKKK5 protein
phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and
activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase
(SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not
activate MAPK/ERK. [provided by RefSeq, Jul 2008]
More
Molecular
Weight(MW)
155KD
Cellular
Localizatio
Cytoplasm, Endoplasmic reticulum
Application
·
IHC
Immunohistochemical
analysis of paraffin-embedded lung cancer tissues using MAP3K5 antibody with
DAB staining.
·
IHC
Immunohistochemical
analysis of paraffin-embedded prostate cancer tissues using MAP3K5 antibody
with DAB staining.
·
ICC/IF
Immunofluorescence
analysis of Hela cells using MAP3K5 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-MAP3K5 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHC
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
MAP3K5
Gene Synonyms
ASK1
MEKK5
MAPKKK5
Gene Full Name
mitogen-activated protein kinase kinase
kinase 5
Gene Summary
Mitogen-activated protein kinase (MAPK)
signaling cascades include MAPK or extracellular signal-regulated kinase
(ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK).
MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase,
MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling
cascades are highly conserved, and homologs exist in yeast, Drosophila, and
mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase
subdomains. Northern blot analysis shows that MAPKKK5 transcript is
abundantly expressed in human heart and pancreas. The MAPKKK5 protein
phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and
activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase
(SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not
activate MAPK/ERK. [provided by RefSeq, Jul 2008]
More
Molecular
Weight(MW)
155KD
Cellular
Localizatio
Cytoplasm, Endoplasmic reticulum
Application
·
IHC
Immunohistochemical
analysis of paraffin-embedded lung cancer tissues using MAP3K5 antibody with
DAB staining.
·
IHC
Immunohistochemical
analysis of paraffin-embedded prostate cancer tissues using MAP3K5 antibody
with DAB staining.
·
ICC/IF
Immunofluorescence
analysis of Hela cells using MAP3K5 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-MAP3K5 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHC
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
MAP3K5
Gene Synonyms
ASK1
MEKK5
MAPKKK5
Gene Full Name
mitogen-activated protein kinase kinase
kinase 5
Gene Summary
Mitogen-activated protein kinase (MAPK)
signaling cascades include MAPK or extracellular signal-regulated kinase
(ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK).
MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase,
MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling
cascades are highly conserved, and homologs exist in yeast, Drosophila, and
mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase
subdomains. Northern blot analysis shows that MAPKKK5 transcript is
abundantly expressed in human heart and pancreas. The MAPKKK5 protein
phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and
activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase
(SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not
activate MAPK/ERK. [provided by RefSeq, Jul 2008]
More
Molecular
Weight(MW)
155KD
Cellular
Localizatio
Cytoplasm, Endoplasmic reticulum
Application
·
IHC
Immunohistochemical
analysis of paraffin-embedded lung cancer tissues using MAP3K5 antibody with
DAB staining.
·
IHC
Immunohistochemical
analysis of paraffin-embedded prostate cancer tissues using MAP3K5 antibody
with DAB staining.
·
ICC/IF
Immunofluorescence
analysis of Hela cells using MAP3K5 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-MAP3K5 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHC
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
MAP3K5
Gene Synonyms
ASK1
MEKK5
MAPKKK5
Gene Full Name
mitogen-activated protein kinase kinase
kinase 5
Gene Summary
Mitogen-activated protein kinase (MAPK)
signaling cascades include MAPK or extracellular signal-regulated kinase
(ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK).
MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase,
MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling
cascades are highly conserved, and homologs exist in yeast, Drosophila, and
mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase
subdomains. Northern blot analysis shows that MAPKKK5 transcript is
abundantly expressed in human heart and pancreas. The MAPKKK5 protein
phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and
activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase
(SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not
activate MAPK/ERK. [provided by RefSeq, Jul 2008]
More
Molecular
Weight(MW)
155KD
Cellular
Localizatio
Cytoplasm, Endoplasmic reticulum
Application
·
IHC
Immunohistochemical
analysis of paraffin-embedded lung cancer tissues using MAP3K5 antibody with
DAB staining.
·
IHC
Immunohistochemical
analysis of paraffin-embedded prostate cancer tissues using MAP3K5 antibody
with DAB staining.
·
ICC/IF
Immunofluorescence
analysis of Hela cells using MAP3K5 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-MAP3K5 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHC
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
MAP3K5
Gene Synonyms
ASK1
MEKK5
MAPKKK5
Gene Full Name
mitogen-activated protein kinase kinase
kinase 5
Gene Summary
Mitogen-activated protein kinase (MAPK)
signaling cascades include MAPK or extracellular signal-regulated kinase
(ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK).
MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase,
MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling
cascades are highly conserved, and homologs exist in yeast, Drosophila, and
mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase
subdomains. Northern blot analysis shows that MAPKKK5 transcript is
abundantly expressed in human heart and pancreas. The MAPKKK5 protein
phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and
activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase
(SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not
activate MAPK/ERK. [provided by RefSeq, Jul 2008]
More
Molecular
Weight(MW)
155KD
Cellular
Localizatio
Cytoplasm, Endoplasmic reticulum
Application
·
IHC
Immunohistochemical
analysis of paraffin-embedded lung cancer tissues using MAP3K5 antibody with
DAB staining.
·
IHC
Immunohistochemical
analysis of paraffin-embedded prostate cancer tissues using MAP3K5 antibody
with DAB staining.
·
ICC/IF
Immunofluorescence
analysis of Hela cells using MAP3K5 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-MAP3K5 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHC
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
MAP3K5
Gene Synonyms
ASK1
MEKK5
MAPKKK5
Gene Full Name
mitogen-activated protein kinase kinase
kinase 5
Gene Summary
Mitogen-activated protein kinase (MAPK)
signaling cascades include MAPK or extracellular signal-regulated kinase
(ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK).
MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase,
MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling
cascades are highly conserved, and homologs exist in yeast, Drosophila, and
mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase
subdomains. Northern blot analysis shows that MAPKKK5 transcript is
abundantly expressed in human heart and pancreas. The MAPKKK5 protein
phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and
activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase
(SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not
activate MAPK/ERK. [provided by RefSeq, Jul 2008]
More
Molecular
Weight(MW)
155KD
Cellular
Localizatio
Cytoplasm, Endoplasmic reticulum
Application
·
IHC
Immunohistochemical
analysis of paraffin-embedded lung cancer tissues using MAP3K5 antibody with
DAB staining.
·
IHC
Immunohistochemical
analysis of paraffin-embedded prostate cancer tissues using MAP3K5 antibody
with DAB staining.
·
ICC/IF
Immunofluorescence
analysis of Hela cells using MAP3K5 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-MAP3K5 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHC
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
MAP3K5
Gene Synonyms
ASK1
MEKK5
MAPKKK5
Gene Full Name
mitogen-activated protein kinase kinase
kinase 5
Gene Summary
Mitogen-activated protein kinase (MAPK)
signaling cascades include MAPK or extracellular signal-regulated kinase
(ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK).
MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase,
MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling
cascades are highly conserved, and homologs exist in yeast, Drosophila, and
mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase
subdomains. Northern blot analysis shows that MAPKKK5 transcript is
abundantly expressed in human heart and pancreas. The MAPKKK5 protein
phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and
activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase
(SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not
activate MAPK/ERK. [provided by RefSeq, Jul 2008]
More
Molecular
Weight(MW)
155KD
Cellular
Localizatio
Cytoplasm, Endoplasmic reticulum
Application
·
IHC
Immunohistochemical
analysis of paraffin-embedded lung cancer tissues using MAP3K5 antibody with
DAB staining.
·
IHC
Immunohistochemical
analysis of paraffin-embedded prostate cancer tissues using MAP3K5 antibody
with DAB staining.
·
ICC/IF
Immunofluorescence
analysis of Hela cells using MAP3K5 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-MAP3K5 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHC
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
MAP3K5
Gene Synonyms
ASK1
MEKK5
MAPKKK5
Gene Full Name
mitogen-activated protein kinase kinase
kinase 5
Gene Summary
Mitogen-activated protein kinase (MAPK)
signaling cascades include MAPK or extracellular signal-regulated kinase
(ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK).
MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase,
MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling
cascades are highly conserved, and homologs exist in yeast, Drosophila, and
mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase
subdomains. Northern blot analysis shows that MAPKKK5 transcript is
abundantly expressed in human heart and pancreas. The MAPKKK5 protein
phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and
activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase
(SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not
activate MAPK/ERK. [provided by RefSeq, Jul 2008]
More
Molecular
Weight(MW)
155KD
Cellular
Localizatio
Cytoplasm, Endoplasmic reticulum
Application
·
IHC
Immunohistochemical
analysis of paraffin-embedded lung cancer tissues using MAP3K5 antibody with
DAB staining.
·
IHC
Immunohistochemical
analysis of paraffin-embedded prostate cancer tissues using MAP3K5 antibody
with DAB staining.
·
ICC/IF
Immunofluorescence
analysis of Hela cells using MAP3K5 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-MAP3K5 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHC
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
MAP3K5
Gene Synonyms
ASK1
MEKK5
MAPKKK5
Gene Full Name
mitogen-activated protein kinase kinase
kinase 5
Gene Summary
Mitogen-activated protein kinase (MAPK)
signaling cascades include MAPK or extracellular signal-regulated kinase
(ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK).
MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase,
MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling
cascades are highly conserved, and homologs exist in yeast, Drosophila, and
mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase
subdomains. Northern blot analysis shows that MAPKKK5 transcript is
abundantly expressed in human heart and pancreas. The MAPKKK5 protein
phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and
activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase
(SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not
activate MAPK/ERK. [provided by RefSeq, Jul 2008]
More
Molecular
Weight(MW)
155KD
Cellular
Localizatio
Cytoplasm, Endoplasmic reticulum
Application
·
IHC
Immunohistochemical
analysis of paraffin-embedded lung cancer tissues using MAP3K5 antibody with
DAB staining.
·
IHC
Immunohistochemical
analysis of paraffin-embedded prostate cancer tissues using MAP3K5 antibody
with DAB staining.
·
ICC/IF
Immunofluorescence
analysis of Hela cells using MAP3K5 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-MAP3K5 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHC
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
MAP3K5
Gene Synonyms
ASK1
MEKK5
MAPKKK5
Gene Full Name
mitogen-activated protein kinase kinase
kinase 5
Gene Summary
Mitogen-activated protein kinase (MAPK)
signaling cascades include MAPK or extracellular signal-regulated kinase
(ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK).
MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase,
MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling
cascades are highly conserved, and homologs exist in yeast, Drosophila, and
mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase
subdomains. Northern blot analysis shows that MAPKKK5 transcript is
abundantly expressed in human heart and pancreas. The MAPKKK5 protein
phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and
activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase
(SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not
activate MAPK/ERK. [provided by RefSeq, Jul 2008]
More
Molecular
Weight(MW)
155KD
Cellular
Localizatio
Cytoplasm, Endoplasmic reticulum
Application
·
IHC
Immunohistochemical
analysis of paraffin-embedded lung cancer tissues using MAP3K5 antibody with
DAB staining.
·
IHC
Immunohistochemical
analysis of paraffin-embedded prostate cancer tissues using MAP3K5 antibody
with DAB staining.
·
ICC/IF
Immunofluorescence
analysis of Hela cells using MAP3K5 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-MAP3K5 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHC
IHC:1:200-1:2000
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
MAP3K5
Gene Synonyms
ASK1
Gene Full Name
mitogen-activated protein kinase kinase
kinase 5
Gene Summary
Mitogen-activated protein kinase (MAPK)
signaling cascades include MAPK or extracellular signal-regulated kinase
(ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK).
MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase,
MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling
cascades are highly conserved, and homologs exist in yeast, Drosophila, and
mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase
subdomains. Northern blot analysis shows that MAPKKK5 transcript is
abundantly expressed in human heart and pancreas. The MAPKKK5 protein
phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and
activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase
(SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not
activate MAPK/ERK. [provided by RefSeq, Jul 2008]
More
Molecular
Weight(MW)
155KD
Cellular
Localizatio
Cytoplasm, Endoplasmic reticulum
Application
ICC/IF:1:100-1:500
MEKK5
MAPKKK5
·
IHC
Immunohistochemical analysis of paraffin-embedded lung cancer tissues using MAP3K5 antibody with DAB staining.
·
IHC
Immunohistochemical analysis of paraffin-embedded prostate cancer tissues using MAP3K5 antibody with DAB staining.
·
ICC/IF
Immunofluorescence analysis of Hela cells using MAP3K5 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
|
Application Notes |
IHC:1:200-1:2000 |
Additional Information
|
Form |
Liquid |
|
Storage Instruction |
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
|
Storage Buffer |
Purified antibody in PBS with 0.05% sodium azide. |
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