![]() |
产地 | 上海 |
品牌 | OminimAbs |
保存条件 | |
货号 | OM641708 |
用途 | 实验研究 |
应用范围 | 科研实验 |
抗原来源 | 电询 |
保质期 | 2年 |
抗体名 | 电询 |
是否单克隆 | 否 |
克隆性 | 否 |
靶点 | 电询 |
适应物种 | 电询 |
形态 | 电询 |
宿主 | 电询 |
标记物 | 电询 |
包装规格 | 毫升 |
亚型 | 电询 |
标识物 | 电询 |
浓度 | 电询% |
免疫原 | 电询 |
是否进口 | 否 |
Product Profile
Product Name
Anti-NR3C1 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHC
IHC:1:200-1:2000
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
NR3C1
Gene Synonyms
GR
Hide
Gene Full Name
nuclear receptor subfamily 3 group C
member 1
Gene Summary
This gene encodes glucocorticoid
receptor, which can function both as a transcription factor that binds to
glucocorticoid response elements in the promoters of glucocorticoid
responsive genes to activate their transcription, and as a regulator of other
transcription factors. This receptor is typically found in the cytoplasm, but
upon ligand binding, is transported into the nucleus. It is involved in
inflammatory responses, cellular proliferation, and differentiation in target
tissues. Mutations in this gene are associated with generalized
glucocorticoid resistance. Alternative splicing of this gene results in
transcript variants encoding either the same or different isoforms.
Additional isoforms resulting from the use of alternate in-frame translation
initiation sites have also been described, and shown to be functional,
displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct
transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
Hide
Molecular
Weight(MW)
86KD
Cellular
Localizatio
Cytoplasm, Cytoskeleton, Mitochondrion,
Nucleus
Application
ICC/IF:1:100-1:500
GCR
GRL
GCCR
GCRST
IHC
Immunohistochemical analysis of paraffin-embedded liver cancer tissues using NR3C1 antibody with DAB staining.
·
IHC
Immunohistochemical analysis of paraffin-embedded breast cancer tissues using NR3C1 antibody with DAB staining.
·
ICC/IF
Immunofluorescence analysis of Hela cells using NR3C1 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application Notes |
IHC:1:200-1:2000 |
Additional Information
Form |
Liquid |
Storage Instruction |
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
Storage Buffer |
Purified antibody in PBS with 0.05% sodium azide. |