|
- 品牌：OminimAbs
- 产地：上海
- 型号：毫升
- 货号：OM641708
- 发布日期： 2024-09-10
- 更新日期： 2024-10-09
| 产地 | 上海 |
| 品牌 | OminimAbs |
| 保存条件 | |
| 货号 | OM641708 |
| 用途 | 实验研究 |
| 应用范围 | 科研实验 |
| 抗原来源 | 电询 |
| 保质期 | 2年 |
| 抗体名 | 电询 |
| 是否单克隆 | 否 |
| 克隆性 | 否 |
| 靶点 | 电询 |
| 适应物种 | 电询 |
| 形态 | 电询 |
| 宿主 | 电询 |
| 标记物 | 电询 |
| 包装规格 | 毫升 |
| 亚型 | 电询 |
| 标识物 | 电询 |
| 浓度 | 电询% |
| 免疫原 | 电询 |
| 是否进口 | 否 |
Product Profile
Product Name
Anti-ERBB2 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
ERBB2
Gene Synonyms
NEU
NGL
HER2
TKR1
CD340
HER-2
VSCN2
MLN 19
MLN-19
c-ERB2
c-ERB-2
HER-2/neu
p185(erbB2)
Hide
Gene Full Name
erb-b2 receptor tyrosine kinase 2
Gene Summary
This gene encodes a member of the
epidermal growth factor (EGF) receptor family of receptor tyrosine kinases.
This protein has no ligand binding domain of its own and therefore cannot
bind growth factors. However, it does bind tightly to other ligand-bound EGF
receptor family members to form a heterodimer, stabilizing ligand binding and
enhancing kinase-mediated activation of downstream signalling pathways, such
as those involving mitogen-activated protein kinase and
phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654
and 655 of isoform a (positions 624 and 625 of isoform b) have been reported,
with the most common allele, Ile654/Ile655, shown here. Amplification and/or
overexpression of this gene has been reported in numerous cancers, including
breast and ovarian tumors. Alternative splicing results in several additional
transcript variants, some encoding different isoforms and others that have
not been fully characterized. [provided by RefSeq, Jul 2008]
Hide
Molecular
Weight(MW)
63KD
Cellular
Localizatio
Cytoplasm,Nucleus and Cell membrane
Application
·
WB
Western blot
analysis using ERBB2 antibody against Hek293(1), Hela(2),Cos7(3),HepG2(4) cell
lysate.
·
IHC
Immunohistochemical
analysis of paraffin-embedded breast cancer tissues using ERBB2 antibody with
DAB staining.
·
ICC/IF
Immunofluorescence
analysis of A549 cells using ERBB2 antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
WB:1:200-1:2000
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-ERBB2 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
ERBB2
Gene Synonyms
NEU
NGL
HER2
TKR1
CD340
HER-2
VSCN2
MLN 19
MLN-19
c-ERB2
c-ERB-2
HER-2/neu
p185(erbB2)
Hide
Gene Full Name
erb-b2 receptor tyrosine kinase 2
Gene Summary
This gene encodes a member of the
epidermal growth factor (EGF) receptor family of receptor tyrosine kinases.
This protein has no ligand binding domain of its own and therefore cannot
bind growth factors. However, it does bind tightly to other ligand-bound EGF
receptor family members to form a heterodimer, stabilizing ligand binding and
enhancing kinase-mediated activation of downstream signalling pathways, such
as those involving mitogen-activated protein kinase and
phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654
and 655 of isoform a (positions 624 and 625 of isoform b) have been reported,
with the most common allele, Ile654/Ile655, shown here. Amplification and/or
overexpression of this gene has been reported in numerous cancers, including
breast and ovarian tumors. Alternative splicing results in several additional
transcript variants, some encoding different isoforms and others that have
not been fully characterized. [provided by RefSeq, Jul 2008]
Hide
Molecular
Weight(MW)
63KD
Cellular
Localizatio
Cytoplasm,Nucleus and Cell membrane
Application
·
WB
Western blot
analysis using ERBB2 antibody against Hek293(1), Hela(2),Cos7(3),HepG2(4) cell
lysate.
·
IHC
Immunohistochemical
analysis of paraffin-embedded breast cancer tissues using ERBB2 antibody with
DAB staining.
·
ICC/IF
Immunofluorescence
analysis of A549 cells using ERBB2 antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
WB:1:200-1:2000
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-ERBB2 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
ERBB2
Gene Synonyms
NEU
NGL
HER2
TKR1
CD340
HER-2
VSCN2
MLN 19
MLN-19
c-ERB2
c-ERB-2
HER-2/neu
p185(erbB2)
Hide
Gene Full Name
erb-b2 receptor tyrosine kinase 2
Gene Summary
This gene encodes a member of the
epidermal growth factor (EGF) receptor family of receptor tyrosine kinases.
This protein has no ligand binding domain of its own and therefore cannot
bind growth factors. However, it does bind tightly to other ligand-bound EGF
receptor family members to form a heterodimer, stabilizing ligand binding and
enhancing kinase-mediated activation of downstream signalling pathways, such
as those involving mitogen-activated protein kinase and
phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654
and 655 of isoform a (positions 624 and 625 of isoform b) have been reported,
with the most common allele, Ile654/Ile655, shown here. Amplification and/or
overexpression of this gene has been reported in numerous cancers, including
breast and ovarian tumors. Alternative splicing results in several additional
transcript variants, some encoding different isoforms and others that have
not been fully characterized. [provided by RefSeq, Jul 2008]
Hide
Molecular
Weight(MW)
63KD
Cellular
Localizatio
Cytoplasm,Nucleus and Cell membrane
Application
·
WB
Western blot
analysis using ERBB2 antibody against Hek293(1), Hela(2),Cos7(3),HepG2(4) cell
lysate.
·
IHC
Immunohistochemical
analysis of paraffin-embedded breast cancer tissues using ERBB2 antibody with
DAB staining.
·
ICC/IF
Immunofluorescence
analysis of A549 cells using ERBB2 antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
WB:1:200-1:2000
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-ERBB2 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
ERBB2
Gene Synonyms
NEU
NGL
HER2
TKR1
CD340
HER-2
VSCN2
MLN 19
MLN-19
c-ERB2
c-ERB-2
HER-2/neu
p185(erbB2)
Hide
Gene Full Name
erb-b2 receptor tyrosine kinase 2
Gene Summary
This gene encodes a member of the
epidermal growth factor (EGF) receptor family of receptor tyrosine kinases.
This protein has no ligand binding domain of its own and therefore cannot
bind growth factors. However, it does bind tightly to other ligand-bound EGF
receptor family members to form a heterodimer, stabilizing ligand binding and
enhancing kinase-mediated activation of downstream signalling pathways, such
as those involving mitogen-activated protein kinase and
phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654
and 655 of isoform a (positions 624 and 625 of isoform b) have been reported,
with the most common allele, Ile654/Ile655, shown here. Amplification and/or
overexpression of this gene has been reported in numerous cancers, including
breast and ovarian tumors. Alternative splicing results in several additional
transcript variants, some encoding different isoforms and others that have
not been fully characterized. [provided by RefSeq, Jul 2008]
Hide
Molecular
Weight(MW)
63KD
Cellular
Localizatio
Cytoplasm,Nucleus and Cell membrane
Application
·
WB
Western blot
analysis using ERBB2 antibody against Hek293(1), Hela(2),Cos7(3),HepG2(4) cell
lysate.
·
IHC
Immunohistochemical
analysis of paraffin-embedded breast cancer tissues using ERBB2 antibody with
DAB staining.
·
ICC/IF
Immunofluorescence
analysis of A549 cells using ERBB2 antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
WB:1:200-1:2000
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-ERBB2 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
ERBB2
Gene Synonyms
NEU
NGL
HER2
TKR1
CD340
HER-2
VSCN2
MLN 19
MLN-19
c-ERB2
c-ERB-2
HER-2/neu
p185(erbB2)
Hide
Gene Full Name
erb-b2 receptor tyrosine kinase 2
Gene Summary
This gene encodes a member of the
epidermal growth factor (EGF) receptor family of receptor tyrosine kinases.
This protein has no ligand binding domain of its own and therefore cannot
bind growth factors. However, it does bind tightly to other ligand-bound EGF
receptor family members to form a heterodimer, stabilizing ligand binding and
enhancing kinase-mediated activation of downstream signalling pathways, such
as those involving mitogen-activated protein kinase and
phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654
and 655 of isoform a (positions 624 and 625 of isoform b) have been reported,
with the most common allele, Ile654/Ile655, shown here. Amplification and/or
overexpression of this gene has been reported in numerous cancers, including
breast and ovarian tumors. Alternative splicing results in several additional
transcript variants, some encoding different isoforms and others that have
not been fully characterized. [provided by RefSeq, Jul 2008]
Hide
Molecular
Weight(MW)
63KD
Cellular
Localizatio
Cytoplasm,Nucleus and Cell membrane
Application
·
WB
Western blot
analysis using ERBB2 antibody against Hek293(1), Hela(2),Cos7(3),HepG2(4) cell
lysate.
·
IHC
Immunohistochemical
analysis of paraffin-embedded breast cancer tissues using ERBB2 antibody with
DAB staining.
·
ICC/IF
Immunofluorescence
analysis of A549 cells using ERBB2 antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
WB:1:200-1:2000
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-ERBB2 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
ERBB2
Gene Synonyms
NEU
NGL
HER2
TKR1
CD340
HER-2
VSCN2
MLN 19
MLN-19
c-ERB2
c-ERB-2
HER-2/neu
p185(erbB2)
Hide
Gene Full Name
erb-b2 receptor tyrosine kinase 2
Gene Summary
This gene encodes a member of the
epidermal growth factor (EGF) receptor family of receptor tyrosine kinases.
This protein has no ligand binding domain of its own and therefore cannot
bind growth factors. However, it does bind tightly to other ligand-bound EGF
receptor family members to form a heterodimer, stabilizing ligand binding and
enhancing kinase-mediated activation of downstream signalling pathways, such
as those involving mitogen-activated protein kinase and
phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654
and 655 of isoform a (positions 624 and 625 of isoform b) have been reported,
with the most common allele, Ile654/Ile655, shown here. Amplification and/or
overexpression of this gene has been reported in numerous cancers, including
breast and ovarian tumors. Alternative splicing results in several additional
transcript variants, some encoding different isoforms and others that have
not been fully characterized. [provided by RefSeq, Jul 2008]
Hide
Molecular
Weight(MW)
63KD
Cellular
Localizatio
Cytoplasm,Nucleus and Cell membrane
Application
·
WB
Western blot
analysis using ERBB2 antibody against Hek293(1), Hela(2),Cos7(3),HepG2(4) cell
lysate.
·
IHC
Immunohistochemical
analysis of paraffin-embedded breast cancer tissues using ERBB2 antibody with
DAB staining.
·
ICC/IF
Immunofluorescence
analysis of A549 cells using ERBB2 antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
WB:1:200-1:2000
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-ERBB2 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
ERBB2
Gene Synonyms
NEU
NGL
HER2
TKR1
CD340
HER-2
VSCN2
MLN 19
MLN-19
c-ERB2
c-ERB-2
HER-2/neu
p185(erbB2)
Hide
Gene Full Name
erb-b2 receptor tyrosine kinase 2
Gene Summary
This gene encodes a member of the
epidermal growth factor (EGF) receptor family of receptor tyrosine kinases.
This protein has no ligand binding domain of its own and therefore cannot
bind growth factors. However, it does bind tightly to other ligand-bound EGF
receptor family members to form a heterodimer, stabilizing ligand binding and
enhancing kinase-mediated activation of downstream signalling pathways, such
as those involving mitogen-activated protein kinase and
phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654
and 655 of isoform a (positions 624 and 625 of isoform b) have been reported,
with the most common allele, Ile654/Ile655, shown here. Amplification and/or
overexpression of this gene has been reported in numerous cancers, including
breast and ovarian tumors. Alternative splicing results in several additional
transcript variants, some encoding different isoforms and others that have
not been fully characterized. [provided by RefSeq, Jul 2008]
Hide
Molecular
Weight(MW)
63KD
Cellular
Localizatio
Cytoplasm,Nucleus and Cell membrane
Application
·
WB
Western blot
analysis using ERBB2 antibody against Hek293(1), Hela(2),Cos7(3),HepG2(4) cell
lysate.
·
IHC
Immunohistochemical
analysis of paraffin-embedded breast cancer tissues using ERBB2 antibody with
DAB staining.
·
ICC/IF
Immunofluorescence
analysis of A549 cells using ERBB2 antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
WB:1:200-1:2000
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-ERBB2 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
ERBB2
Gene Synonyms
NEU
NGL
HER2
TKR1
CD340
HER-2
VSCN2
MLN 19
MLN-19
c-ERB2
c-ERB-2
HER-2/neu
p185(erbB2)
Hide
Gene Full Name
erb-b2 receptor tyrosine kinase 2
Gene Summary
This gene encodes a member of the
epidermal growth factor (EGF) receptor family of receptor tyrosine kinases.
This protein has no ligand binding domain of its own and therefore cannot
bind growth factors. However, it does bind tightly to other ligand-bound EGF
receptor family members to form a heterodimer, stabilizing ligand binding and
enhancing kinase-mediated activation of downstream signalling pathways, such
as those involving mitogen-activated protein kinase and
phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654
and 655 of isoform a (positions 624 and 625 of isoform b) have been reported,
with the most common allele, Ile654/Ile655, shown here. Amplification and/or
overexpression of this gene has been reported in numerous cancers, including
breast and ovarian tumors. Alternative splicing results in several additional
transcript variants, some encoding different isoforms and others that have
not been fully characterized. [provided by RefSeq, Jul 2008]
Hide
Molecular
Weight(MW)
63KD
Cellular
Localizatio
Cytoplasm,Nucleus and Cell membrane
Application
·
WB
Western blot
analysis using ERBB2 antibody against Hek293(1), Hela(2),Cos7(3),HepG2(4) cell
lysate.
·
IHC
Immunohistochemical
analysis of paraffin-embedded breast cancer tissues using ERBB2 antibody with
DAB staining.
·
ICC/IF
Immunofluorescence
analysis of A549 cells using ERBB2 antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
WB:1:200-1:2000
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-ERBB2 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
ERBB2
Gene Synonyms
NEU
NGL
HER2
TKR1
CD340
HER-2
VSCN2
MLN 19
MLN-19
c-ERB2
c-ERB-2
HER-2/neu
p185(erbB2)
Hide
Gene Full Name
erb-b2 receptor tyrosine kinase 2
Gene Summary
This gene encodes a member of the
epidermal growth factor (EGF) receptor family of receptor tyrosine kinases.
This protein has no ligand binding domain of its own and therefore cannot
bind growth factors. However, it does bind tightly to other ligand-bound EGF
receptor family members to form a heterodimer, stabilizing ligand binding and
enhancing kinase-mediated activation of downstream signalling pathways, such
as those involving mitogen-activated protein kinase and
phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654
and 655 of isoform a (positions 624 and 625 of isoform b) have been reported,
with the most common allele, Ile654/Ile655, shown here. Amplification and/or
overexpression of this gene has been reported in numerous cancers, including
breast and ovarian tumors. Alternative splicing results in several additional
transcript variants, some encoding different isoforms and others that have
not been fully characterized. [provided by RefSeq, Jul 2008]
Hide
Molecular
Weight(MW)
63KD
Cellular
Localizatio
Cytoplasm,Nucleus and Cell membrane
Application
·
WB
Western blot
analysis using ERBB2 antibody against Hek293(1), Hela(2),Cos7(3),HepG2(4) cell
lysate.
·
IHC
Immunohistochemical
analysis of paraffin-embedded breast cancer tissues using ERBB2 antibody with
DAB staining.
·
ICC/IF
Immunofluorescence
analysis of A549 cells using ERBB2 antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
WB:1:200-1:2000
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-ERBB2 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
Species
Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Protein A
Target Information
Gene Symbol
ERBB2
Gene Synonyms
NEU
Hide
Gene Full Name
erb-b2 receptor tyrosine kinase 2
Gene Summary
This gene encodes a member of the
epidermal growth factor (EGF) receptor family of receptor tyrosine kinases.
This protein has no ligand binding domain of its own and therefore cannot
bind growth factors. However, it does bind tightly to other ligand-bound EGF
receptor family members to form a heterodimer, stabilizing ligand binding and
enhancing kinase-mediated activation of downstream signalling pathways, such
as those involving mitogen-activated protein kinase and
phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654
and 655 of isoform a (positions 624 and 625 of isoform b) have been reported,
with the most common allele, Ile654/Ile655, shown here. Amplification and/or
overexpression of this gene has been reported in numerous cancers, including
breast and ovarian tumors. Alternative splicing results in several additional
transcript variants, some encoding different isoforms and others that have
not been fully characterized. [provided by RefSeq, Jul 2008]
Hide
Molecular
Weight(MW)
63KD
Cellular
Localizatio
Cytoplasm,Nucleus and Cell membrane
Application
IHC:1:200-1:2000
ICC/IF:1:100-1:500
NGL
HER2
TKR1
CD340
HER-2
VSCN2
MLN 19
MLN-19
c-ERB2
c-ERB-2
HER-2/neu
p185(erbB2)
·
WB
Western blot analysis using ERBB2 antibody against Hek293(1), Hela(2),Cos7(3),HepG2(4) cell lysate.
·
IHC
Immunohistochemical analysis of paraffin-embedded breast cancer tissues using ERBB2 antibody with DAB staining.
·
ICC/IF
Immunofluorescence analysis of A549 cells using ERBB2 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
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Application Notes |
WB:1:200-1:2000 |
Additional Information
|
Form |
Liquid |
|
Storage Instruction |
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
|
Storage Buffer |
Purified antibody in PBS with 0.05% sodium azide. |
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