|
- 品牌：OminimAbs
- 产地：上海
- 型号：毫升
- 货号：OM641708
- 发布日期： 2024-09-06
- 更新日期： 2024-10-09
| 产地 | 上海 |
| 品牌 | OminimAbs |
| 保存条件 | |
| 货号 | OM641708 |
| 用途 | 实验研究 |
| 应用范围 | 科研实验 |
| 抗原来源 | 电询 |
| 保质期 | 2年 |
| 抗体名 | 电询 |
| 是否单克隆 | 否 |
| 克隆性 | 否 |
| 靶点 | 电询 |
| 适应物种 | 电询 |
| 形态 | 电询 |
| 宿主 | 电询 |
| 标记物 | 电询 |
| 包装规格 | 毫升 |
| 亚型 | 电询 |
| 标识物 | 电询 |
| 浓度 | 电询% |
| 免疫原 | 电询 |
| 是否进口 | 否 |
Product Profile
Product Name
Anti-LIMK1 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
LIMK1
Gene Synonyms
LIMK
LIMK-1
Gene Full Name
LIM domain kinase 1
Gene Summary
There are approximately 40 known
eukaryotic LIM proteins, so named for the LIM domains they contain. LIM
domains are highly conserved cysteine-rich structures containing 2 zinc
fingers. Although zinc fingers usually function by binding to DNA or RNA, the
LIM motif probably mediates protein-protein interactions. LIM kinase-1 and
LIM kinase-2 belong to a small subfamily with a unique combination of 2
N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a
serine/threonine kinase that regulates actin polymerization via
phosphorylation and inactivation of the actin binding factor cofilin. This
protein is ubiquitously expressed during development and plays a role in many
cellular processes associated with cytoskeletal structure. This protein also
stimulates axon growth and may play a role in brain development. LIMK1
hemizygosity is implicated in the impaired visuospatial constructive
cognition of Williams syndrome. Alternative splicing results in multiple
transcript variants encoding distinct isoforms.
Hide
Molecular
Weight(MW)
73 kDa
Cellular
Localizatio
Cell projection, Cytoplasm, Cytoskeleton,
Nucleus
Application
· 
WB
Western blot
analysis using LIMK1 antibody against NIH3T3(1), MCF-7(2) cell lysate.
·
IHC
Immunohistochemical
analysis of paraffin-embedded breast cancer tissues using LIMK1 antibody with
DAB staining.
· 
ICC/IF
Immunofluorescence
analysis of A549 cells using LIMK1 antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-LIMK1 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
LIMK1
Gene Synonyms
LIMK
LIMK-1
Gene Full Name
LIM domain kinase 1
Gene Summary
There are approximately 40 known
eukaryotic LIM proteins, so named for the LIM domains they contain. LIM
domains are highly conserved cysteine-rich structures containing 2 zinc
fingers. Although zinc fingers usually function by binding to DNA or RNA, the
LIM motif probably mediates protein-protein interactions. LIM kinase-1 and
LIM kinase-2 belong to a small subfamily with a unique combination of 2
N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a
serine/threonine kinase that regulates actin polymerization via
phosphorylation and inactivation of the actin binding factor cofilin. This
protein is ubiquitously expressed during development and plays a role in many
cellular processes associated with cytoskeletal structure. This protein also
stimulates axon growth and may play a role in brain development. LIMK1
hemizygosity is implicated in the impaired visuospatial constructive
cognition of Williams syndrome. Alternative splicing results in multiple
transcript variants encoding distinct isoforms.
Hide
Molecular
Weight(MW)
73 kDa
Cellular
Localizatio
Cell projection, Cytoplasm, Cytoskeleton,
Nucleus
Application
·
WB
Western blot
analysis using LIMK1 antibody against NIH3T3(1), MCF-7(2) cell lysate.
·
IHC
Immunohistochemical
analysis of paraffin-embedded breast cancer tissues using LIMK1 antibody with
DAB staining.
·
ICC/IF
Immunofluorescence
analysis of A549 cells using LIMK1 antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-LIMK1 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
LIMK1
Gene Synonyms
LIMK
LIMK-1
Gene Full Name
LIM domain kinase 1
Gene Summary
There are approximately 40 known
eukaryotic LIM proteins, so named for the LIM domains they contain. LIM
domains are highly conserved cysteine-rich structures containing 2 zinc
fingers. Although zinc fingers usually function by binding to DNA or RNA, the
LIM motif probably mediates protein-protein interactions. LIM kinase-1 and
LIM kinase-2 belong to a small subfamily with a unique combination of 2
N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a
serine/threonine kinase that regulates actin polymerization via
phosphorylation and inactivation of the actin binding factor cofilin. This
protein is ubiquitously expressed during development and plays a role in many
cellular processes associated with cytoskeletal structure. This protein also
stimulates axon growth and may play a role in brain development. LIMK1
hemizygosity is implicated in the impaired visuospatial constructive
cognition of Williams syndrome. Alternative splicing results in multiple
transcript variants encoding distinct isoforms.
Hide
Molecular
Weight(MW)
73 kDa
Cellular
Localizatio
Cell projection, Cytoplasm, Cytoskeleton,
Nucleus
Application
·
WB
Western blot
analysis using LIMK1 antibody against NIH3T3(1), MCF-7(2) cell lysate.
·
IHC
Immunohistochemical
analysis of paraffin-embedded breast cancer tissues using LIMK1 antibody with
DAB staining.
·
ICC/IF
Immunofluorescence
analysis of A549 cells using LIMK1 antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-LIMK1 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
LIMK1
Gene Synonyms
LIMK
LIMK-1
Gene Full Name
LIM domain kinase 1
Gene Summary
There are approximately 40 known
eukaryotic LIM proteins, so named for the LIM domains they contain. LIM
domains are highly conserved cysteine-rich structures containing 2 zinc
fingers. Although zinc fingers usually function by binding to DNA or RNA, the
LIM motif probably mediates protein-protein interactions. LIM kinase-1 and
LIM kinase-2 belong to a small subfamily with a unique combination of 2
N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a
serine/threonine kinase that regulates actin polymerization via
phosphorylation and inactivation of the actin binding factor cofilin. This
protein is ubiquitously expressed during development and plays a role in many
cellular processes associated with cytoskeletal structure. This protein also
stimulates axon growth and may play a role in brain development. LIMK1
hemizygosity is implicated in the impaired visuospatial constructive
cognition of Williams syndrome. Alternative splicing results in multiple
transcript variants encoding distinct isoforms.
Hide
Molecular
Weight(MW)
73 kDa
Cellular
Localizatio
Cell projection, Cytoplasm, Cytoskeleton,
Nucleus
Application
·
WB
Western blot
analysis using LIMK1 antibody against NIH3T3(1), MCF-7(2) cell lysate.
·
IHC
Immunohistochemical
analysis of paraffin-embedded breast cancer tissues using LIMK1 antibody with
DAB staining.
·
ICC/IF
Immunofluorescence
analysis of A549 cells using LIMK1 antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-LIMK1 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
LIMK1
Gene Synonyms
LIMK
LIMK-1
Gene Full Name
LIM domain kinase 1
Gene Summary
There are approximately 40 known
eukaryotic LIM proteins, so named for the LIM domains they contain. LIM
domains are highly conserved cysteine-rich structures containing 2 zinc
fingers. Although zinc fingers usually function by binding to DNA or RNA, the
LIM motif probably mediates protein-protein interactions. LIM kinase-1 and
LIM kinase-2 belong to a small subfamily with a unique combination of 2
N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a
serine/threonine kinase that regulates actin polymerization via
phosphorylation and inactivation of the actin binding factor cofilin. This
protein is ubiquitously expressed during development and plays a role in many
cellular processes associated with cytoskeletal structure. This protein also
stimulates axon growth and may play a role in brain development. LIMK1
hemizygosity is implicated in the impaired visuospatial constructive
cognition of Williams syndrome. Alternative splicing results in multiple
transcript variants encoding distinct isoforms.
Hide
Molecular
Weight(MW)
73 kDa
Cellular
Localizatio
Cell projection, Cytoplasm, Cytoskeleton,
Nucleus
Application
·
WB
Western blot
analysis using LIMK1 antibody against NIH3T3(1), MCF-7(2) cell lysate.
·
IHC
Immunohistochemical
analysis of paraffin-embedded breast cancer tissues using LIMK1 antibody with
DAB staining.
·
ICC/IF
Immunofluorescence
analysis of A549 cells using LIMK1 antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-LIMK1 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
LIMK1
Gene Synonyms
LIMK
LIMK-1
Gene Full Name
LIM domain kinase 1
Gene Summary
There are approximately 40 known
eukaryotic LIM proteins, so named for the LIM domains they contain. LIM
domains are highly conserved cysteine-rich structures containing 2 zinc
fingers. Although zinc fingers usually function by binding to DNA or RNA, the
LIM motif probably mediates protein-protein interactions. LIM kinase-1 and
LIM kinase-2 belong to a small subfamily with a unique combination of 2
N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a
serine/threonine kinase that regulates actin polymerization via
phosphorylation and inactivation of the actin binding factor cofilin. This
protein is ubiquitously expressed during development and plays a role in many
cellular processes associated with cytoskeletal structure. This protein also
stimulates axon growth and may play a role in brain development. LIMK1
hemizygosity is implicated in the impaired visuospatial constructive
cognition of Williams syndrome. Alternative splicing results in multiple
transcript variants encoding distinct isoforms.
Hide
Molecular
Weight(MW)
73 kDa
Cellular
Localizatio
Cell projection, Cytoplasm, Cytoskeleton,
Nucleus
Application
·
WB
Western blot
analysis using LIMK1 antibody against NIH3T3(1), MCF-7(2) cell lysate.
·
IHC
Immunohistochemical
analysis of paraffin-embedded breast cancer tissues using LIMK1 antibody with
DAB staining.
·
ICC/IF
Immunofluorescence
analysis of A549 cells using LIMK1 antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-LIMK1 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
LIMK1
Gene Synonyms
LIMK
LIMK-1
Gene Full Name
LIM domain kinase 1
Gene Summary
There are approximately 40 known
eukaryotic LIM proteins, so named for the LIM domains they contain. LIM
domains are highly conserved cysteine-rich structures containing 2 zinc
fingers. Although zinc fingers usually function by binding to DNA or RNA, the
LIM motif probably mediates protein-protein interactions. LIM kinase-1 and
LIM kinase-2 belong to a small subfamily with a unique combination of 2
N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a
serine/threonine kinase that regulates actin polymerization via
phosphorylation and inactivation of the actin binding factor cofilin. This
protein is ubiquitously expressed during development and plays a role in many
cellular processes associated with cytoskeletal structure. This protein also
stimulates axon growth and may play a role in brain development. LIMK1
hemizygosity is implicated in the impaired visuospatial constructive
cognition of Williams syndrome. Alternative splicing results in multiple
transcript variants encoding distinct isoforms.
Hide
Molecular
Weight(MW)
73 kDa
Cellular
Localizatio
Cell projection, Cytoplasm, Cytoskeleton,
Nucleus
Application
·
WB
Western blot
analysis using LIMK1 antibody against NIH3T3(1), MCF-7(2) cell lysate.
·
IHC
Immunohistochemical
analysis of paraffin-embedded breast cancer tissues using LIMK1 antibody with
DAB staining.
·
ICC/IF
Immunofluorescence
analysis of A549 cells using LIMK1 antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-LIMK1 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
LIMK1
Gene Synonyms
LIMK
LIMK-1
Gene Full Name
LIM domain kinase 1
Gene Summary
There are approximately 40 known
eukaryotic LIM proteins, so named for the LIM domains they contain. LIM
domains are highly conserved cysteine-rich structures containing 2 zinc
fingers. Although zinc fingers usually function by binding to DNA or RNA, the
LIM motif probably mediates protein-protein interactions. LIM kinase-1 and
LIM kinase-2 belong to a small subfamily with a unique combination of 2
N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a
serine/threonine kinase that regulates actin polymerization via
phosphorylation and inactivation of the actin binding factor cofilin. This
protein is ubiquitously expressed during development and plays a role in many
cellular processes associated with cytoskeletal structure. This protein also
stimulates axon growth and may play a role in brain development. LIMK1
hemizygosity is implicated in the impaired visuospatial constructive
cognition of Williams syndrome. Alternative splicing results in multiple
transcript variants encoding distinct isoforms.
Hide
Molecular
Weight(MW)
73 kDa
Cellular
Localizatio
Cell projection, Cytoplasm, Cytoskeleton,
Nucleus
Application
·
WB
Western blot
analysis using LIMK1 antibody against NIH3T3(1), MCF-7(2) cell lysate.
·
IHC
Immunohistochemical
analysis of paraffin-embedded breast cancer tissues using LIMK1 antibody with
DAB staining.
·
ICC/IF
Immunofluorescence
analysis of A549 cells using LIMK1 antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-LIMK1 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
LIMK1
Gene Synonyms
LIMK
LIMK-1
Gene Full Name
LIM domain kinase 1
Gene Summary
There are approximately 40 known
eukaryotic LIM proteins, so named for the LIM domains they contain. LIM
domains are highly conserved cysteine-rich structures containing 2 zinc
fingers. Although zinc fingers usually function by binding to DNA or RNA, the
LIM motif probably mediates protein-protein interactions. LIM kinase-1 and
LIM kinase-2 belong to a small subfamily with a unique combination of 2
N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a
serine/threonine kinase that regulates actin polymerization via
phosphorylation and inactivation of the actin binding factor cofilin. This
protein is ubiquitously expressed during development and plays a role in many
cellular processes associated with cytoskeletal structure. This protein also
stimulates axon growth and may play a role in brain development. LIMK1
hemizygosity is implicated in the impaired visuospatial constructive
cognition of Williams syndrome. Alternative splicing results in multiple
transcript variants encoding distinct isoforms.
Hide
Molecular
Weight(MW)
73 kDa
Cellular
Localizatio
Cell projection, Cytoplasm, Cytoskeleton,
Nucleus
Application
·
WB
Western blot
analysis using LIMK1 antibody against NIH3T3(1), MCF-7(2) cell lysate.
·
IHC
Immunohistochemical
analysis of paraffin-embedded breast cancer tissues using LIMK1 antibody with
DAB staining.
·
ICC/IF
Immunofluorescence
analysis of A549 cells using LIMK1 antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-LIMK1 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
LIMK1
Gene Synonyms
LIMK
Gene Full Name
LIM domain kinase 1
Gene Summary
There are approximately 40 known
eukaryotic LIM proteins, so named for the LIM domains they contain. LIM
domains are highly conserved cysteine-rich structures containing 2 zinc
fingers. Although zinc fingers usually function by binding to DNA or RNA, the
LIM motif probably mediates protein-protein interactions. LIM kinase-1 and
LIM kinase-2 belong to a small subfamily with a unique combination of 2
N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a
serine/threonine kinase that regulates actin polymerization via
phosphorylation and inactivation of the actin binding factor cofilin. This
protein is ubiquitously expressed during development and plays a role in many
cellular processes associated with cytoskeletal structure. This protein also
stimulates axon growth and may play a role in brain development. LIMK1
hemizygosity is implicated in the impaired visuospatial constructive
cognition of Williams syndrome. Alternative splicing results in multiple
transcript variants encoding distinct isoforms.
Hide
Molecular
Weight(MW)
73 kDa
Cellular
Localizatio
Cell projection, Cytoplasm, Cytoskeleton,
Nucleus
Application
IHC:1:200-1:1000
ICC/IF:1:100-1:500
LIMK-1
·
WB
Western blot analysis using LIMK1 antibody against NIH3T3(1), MCF-7(2) cell lysate.
·
IHC
Immunohistochemical analysis of paraffin-embedded breast cancer tissues using LIMK1 antibody with DAB staining.
·
ICC/IF
Immunofluorescence analysis of A549 cells using LIMK1 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
|
Application Notes |
WB:1:200-1:2000 |
Additional Information
|
Form |
Liquid |
|
Storage Instruction |
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
|
Storage Buffer |
Purified antibody in PBS with 0.05% sodium azide. |
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