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产地 | 上海 |
品牌 | OminimAbs |
保存条件 | |
货号 | OM641708 |
用途 | 实验研究 |
应用范围 | 科研实验 |
抗原来源 | 电询 |
保质期 | 2年 |
抗体名 | 电询 |
是否单克隆 | 否 |
克隆性 | 否 |
靶点 | 电询 |
适应物种 | 电询 |
形态 | 电询 |
宿主 | 电询 |
标记物 | 电询 |
包装规格 | 毫升 |
亚型 | 电询 |
标识物 | 电询 |
浓度 | 电询% |
免疫原 | 电询 |
是否进口 | 否 |
Product Profile
Product Name
Anti-ADAMTS4 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
ADAMTS4
Gene Synonyms
ADMP-1
Gene Full Name
ADAM metallopeptidase with thrombospondin
type 1 motif 4
Gene Summary
This gene encodes a member of the ADAMTS
(a disintegrin and metalloproteinase with thrombospondin motifs) protein
family. Members of this family share several distinct protein modules,
including a propeptide region, a metalloproteinase domain, a disintegrin-like
domain, and a thrombospondin type 1 (TS) motif. Individual members of this
family differ in the number of C-terminal TS motifs, and some have unique
C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS
motif. The encoded preproprotein is proteolytically processed to generate the
mature protease. This protease is responsible for the degradation of
aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific
extracellular matrix protein. The expression of this gene is upregulated in
arthritic disease and this may contribute to disease progression through the
degradation of aggrecan. Alternative splicing results in multiple transcript
variants, at least one of which encodes an isoform that is proteolytically
processed.
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Molecular
Weight(MW)
90 kDa
Cellular
Localizatio
Extracellular matrix, Secreted
Application
IHC:1:200-1:1000
ICC/IF:1:100-1:500
ADAMTS-2
ADAMTS-4
·
WB
Western blot analysis using ADAMTS4 antibody against MCF-7(1) cell lysate.
·
IHC
Immunohistochemical analysis of paraffin-embedded breast cancer tissues using ADAMTS4 antibody with DAB staining.
·
ICC/IF
Immunofluorescence analysis of A549 cells using ADAMTS4 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application Notes |
WB:1:200-1:2000 |
Additional Information
Form |
Liquid |
Storage Instruction |
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
Storage Buffer |
Purified antibody in PBS with 0.05% sodium azide. |