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产地 | 上海 |
品牌 | OminimAbs |
保存条件 | |
货号 | OM641708 |
用途 | 实验研究 |
应用范围 | 科研实验 |
抗原来源 | 电询 |
保质期 | 2年 |
抗体名 | 电询 |
是否单克隆 | 否 |
克隆性 | 否 |
靶点 | 电询 |
适应物种 | 电询 |
形态 | 电询 |
宿主 | 电询 |
标记物 | 电询 |
包装规格 | 毫升 |
亚型 | 电询 |
标识物 | 电询 |
浓度 | 电询% |
免疫原 | 电询 |
是否进口 | 否 |
Product Profile
Product Name
Anti-MBD2 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
MBD2
Gene Synonyms
DMTase
Gene Full Name
methyl-CpG binding domain protein 2
Gene Summary
DNA methylation is the major modification
of eukaryotic genomes and plays an essential role in mammalian development.
Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear
proteins related by the presence in each of a methyl-CpG binding domain
(MBD). Each of these proteins, with the exception of MBD3, is capable of
binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress
transcription from methylated gene promoters. The protein encoded by this
gene may function as a mediator of the biological consequences of the
methylation signal. It is also reported that the this protein functions as a
demethylase to activate transcription, as DNA methylation causes gene silencing.
Two transcript variants encoding different isoforms have been found for this
gene.
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Molecular
Weight(MW)
43 kDa
Cellular
Localizatio
Nucleus
Application
IHC:1:200-1:1000
ICC/IF:1:100-1:500
NY-CO-41
·
WB
Western blot analysis using MBD2 antibody against K562(1), Raji(2) cell lysate.
·
IHC
Immunohistochemical analysis of paraffin-embedded lung cancer tissues using MBD2 antibody with DAB staining.
·
ICC/IF
Immunofluorescence analysis of MG-63 cells using MBD2 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application Notes |
WB:1:200-1:2000 |
Additional Information
Form |
Liquid |
Storage Instruction |
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
Storage Buffer |
Purified antibody in PBS with 0.05% sodium azide. |