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产地 | 上海 |
品牌 | OminimAbs |
保存条件 | |
货号 | OM641708 |
用途 | 实验研究 |
应用范围 | 科研实验 |
抗原来源 | 电询 |
保质期 | 2年 |
抗体名 | 电询 |
是否单克隆 | 否 |
克隆性 | 否 |
靶点 | 电询 |
适应物种 | 电询 |
形态 | 电询 |
宿主 | 电询 |
标记物 | 电询 |
包装规格 | 毫升 |
亚型 | 电询 |
标识物 | 电询 |
浓度 | 电询% |
免疫原 | 电询 |
是否进口 | 否 |
Product Profile
Product Name
Anti-DNA Ligase IV antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAIHCWB
WB:1:200-1:2000
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
LIG4
Gene Synonyms
DNLI4
Gene Full Name
DNA ligase 4
Gene Summary
The protein encoded by this gene is a DNA
ligase that joins single-strand breaks in a double-stranded
polydeoxynucleotide in an ATP-dependent reaction. This protein is essential
for V(D)J recombination and DNA double-strand break (DSB) repair through
nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray
repair cross complementing protein 4 (XRCC4), and further interacts with the
DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be
required for NHEJ. The crystal structure of the complex formed by this
protein and XRCC4 has been resolved. Defects in this gene are the cause of
LIG4 syndrome. Alternatively spliced transcript variants encoding the same
protein have been observed. [provided by RefSeq, Jul 2008]
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Molecular
Weight(MW)
104 kDa
Cellular
Localizatio
Nucleus
Application
IHC:1:200-1:1000
LIG4
LIG4S
·
WB
Western blot analysis using DNA Ligase IV antibody against SK-OV-3(1), Rb-1(2) cell lysate.
·
IHC
Immunohistochemical analysis of paraffin-embedded lung cancer tissues using DNA Ligase IV antibody with DAB staining.
Application Notes |
WB:1:200-1:2000 |
Additional Information
Form |
Liquid |
Storage Instruction |
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
Storage Buffer |
Purified antibody in PBS with 0.05% sodium azide. |