|
- 品牌：OminimAbs
- 产地：上海
- 型号：毫升
- 货号：OM641708
- 发布日期： 2024-09-03
- 更新日期： 2024-10-09
| 产地 | 上海 |
| 品牌 | OminimAbs |
| 保存条件 | |
| 货号 | OM641708 |
| 用途 | 实验研究 |
| 应用范围 | 科研实验 |
| 抗原来源 | 电询 |
| 保质期 | 2年 |
| 抗体名 | 电询 |
| 是否单克隆 | 否 |
| 克隆性 | 否 |
| 靶点 | 电询 |
| 适应物种 | 电询 |
| 形态 | 电询 |
| 宿主 | 电询 |
| 标记物 | 电询 |
| 包装规格 | 毫升 |
| 亚型 | 电询 |
| 标识物 | 电询 |
| 浓度 | 电询% |
| 免疫原 | 电询 |
| 是否进口 | 否 |
Product Profile
Product Name
Anti-ROCK1 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IF
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
ROCK1
Gene Synonyms
ROCK-I
P160ROCK
Gene Full Name
Rho associated coiled-coil containing
protein kinase 1
Gene Summary
This gene encodes a protein
serine/threonine kinase that is activated when bound to the GTP-bound form of
Rho. The small GTPase Rho regulates formation of focal adhesions and stress
fibers of fibroblasts, as well as adhesion and aggregation of platelets and
lymphocytes by shuttling between the inactive GDP-bound form and the active
GTP-bound form. Rho is also essential in cytokinesis and plays a role in
transcriptional activation by serum response factor. This protein, a
downstream effector of Rho, phosphorylates and activates LIM kinase, which in
turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A
pseudogene, related to this gene, is also located on chromosome 18. [provided
by RefSeq, Aug 2015]
Hide
Cellular
Localizatio
Cell membrane, Cell projection,
Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane
Application
·
ICC/IF
Immunofluorescence
analysis of A549 cells using ROCK1 antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-ROCK1 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IF
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
ROCK1
Gene Synonyms
ROCK-I
P160ROCK
Gene Full Name
Rho associated coiled-coil containing
protein kinase 1
Gene Summary
This gene encodes a protein
serine/threonine kinase that is activated when bound to the GTP-bound form of
Rho. The small GTPase Rho regulates formation of focal adhesions and stress
fibers of fibroblasts, as well as adhesion and aggregation of platelets and
lymphocytes by shuttling between the inactive GDP-bound form and the active
GTP-bound form. Rho is also essential in cytokinesis and plays a role in
transcriptional activation by serum response factor. This protein, a
downstream effector of Rho, phosphorylates and activates LIM kinase, which in
turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A
pseudogene, related to this gene, is also located on chromosome 18. [provided
by RefSeq, Aug 2015]
Hide
Cellular
Localizatio
Cell membrane, Cell projection,
Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane
Application
·
ICC/IF
Immunofluorescence
analysis of A549 cells using ROCK1 antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-ROCK1 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IF
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
ROCK1
Gene Synonyms
ROCK-I
P160ROCK
Gene Full Name
Rho associated coiled-coil containing
protein kinase 1
Gene Summary
This gene encodes a protein
serine/threonine kinase that is activated when bound to the GTP-bound form of
Rho. The small GTPase Rho regulates formation of focal adhesions and stress
fibers of fibroblasts, as well as adhesion and aggregation of platelets and
lymphocytes by shuttling between the inactive GDP-bound form and the active
GTP-bound form. Rho is also essential in cytokinesis and plays a role in
transcriptional activation by serum response factor. This protein, a
downstream effector of Rho, phosphorylates and activates LIM kinase, which in
turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A
pseudogene, related to this gene, is also located on chromosome 18. [provided
by RefSeq, Aug 2015]
Hide
Cellular
Localizatio
Cell membrane, Cell projection,
Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane
Application
·
ICC/IF
Immunofluorescence
analysis of A549 cells using ROCK1 antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-ROCK1 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IF
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
ROCK1
Gene Synonyms
ROCK-I
P160ROCK
Gene Full Name
Rho associated coiled-coil containing
protein kinase 1
Gene Summary
This gene encodes a protein
serine/threonine kinase that is activated when bound to the GTP-bound form of
Rho. The small GTPase Rho regulates formation of focal adhesions and stress
fibers of fibroblasts, as well as adhesion and aggregation of platelets and
lymphocytes by shuttling between the inactive GDP-bound form and the active
GTP-bound form. Rho is also essential in cytokinesis and plays a role in
transcriptional activation by serum response factor. This protein, a
downstream effector of Rho, phosphorylates and activates LIM kinase, which in
turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A
pseudogene, related to this gene, is also located on chromosome 18. [provided
by RefSeq, Aug 2015]
Hide
Cellular
Localizatio
Cell membrane, Cell projection,
Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane
Application
·
ICC/IF
Immunofluorescence
analysis of A549 cells using ROCK1 antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-ROCK1 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IF
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
ROCK1
Gene Synonyms
ROCK-I
P160ROCK
Gene Full Name
Rho associated coiled-coil containing
protein kinase 1
Gene Summary
This gene encodes a protein
serine/threonine kinase that is activated when bound to the GTP-bound form of
Rho. The small GTPase Rho regulates formation of focal adhesions and stress
fibers of fibroblasts, as well as adhesion and aggregation of platelets and
lymphocytes by shuttling between the inactive GDP-bound form and the active
GTP-bound form. Rho is also essential in cytokinesis and plays a role in
transcriptional activation by serum response factor. This protein, a
downstream effector of Rho, phosphorylates and activates LIM kinase, which in
turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A
pseudogene, related to this gene, is also located on chromosome 18. [provided
by RefSeq, Aug 2015]
Hide
Cellular
Localizatio
Cell membrane, Cell projection,
Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane
Application
·
ICC/IF
Immunofluorescence
analysis of A549 cells using ROCK1 antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-ROCK1 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IF
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
ROCK1
Gene Synonyms
ROCK-I
P160ROCK
Gene Full Name
Rho associated coiled-coil containing
protein kinase 1
Gene Summary
This gene encodes a protein
serine/threonine kinase that is activated when bound to the GTP-bound form of
Rho. The small GTPase Rho regulates formation of focal adhesions and stress
fibers of fibroblasts, as well as adhesion and aggregation of platelets and
lymphocytes by shuttling between the inactive GDP-bound form and the active
GTP-bound form. Rho is also essential in cytokinesis and plays a role in
transcriptional activation by serum response factor. This protein, a
downstream effector of Rho, phosphorylates and activates LIM kinase, which in
turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A
pseudogene, related to this gene, is also located on chromosome 18. [provided
by RefSeq, Aug 2015]
Hide
Cellular
Localizatio
Cell membrane, Cell projection,
Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane
Application
·
ICC/IF
Immunofluorescence
analysis of A549 cells using ROCK1 antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-ROCK1 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IF
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
ROCK1
Gene Synonyms
ROCK-I
P160ROCK
Gene Full Name
Rho associated coiled-coil containing
protein kinase 1
Gene Summary
This gene encodes a protein
serine/threonine kinase that is activated when bound to the GTP-bound form of
Rho. The small GTPase Rho regulates formation of focal adhesions and stress
fibers of fibroblasts, as well as adhesion and aggregation of platelets and
lymphocytes by shuttling between the inactive GDP-bound form and the active
GTP-bound form. Rho is also essential in cytokinesis and plays a role in
transcriptional activation by serum response factor. This protein, a
downstream effector of Rho, phosphorylates and activates LIM kinase, which in
turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A
pseudogene, related to this gene, is also located on chromosome 18. [provided
by RefSeq, Aug 2015]
Hide
Cellular
Localizatio
Cell membrane, Cell projection,
Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane
Application
·
ICC/IF
Immunofluorescence
analysis of A549 cells using ROCK1 antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-ROCK1 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IF
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
ROCK1
Gene Synonyms
ROCK-I
P160ROCK
Gene Full Name
Rho associated coiled-coil containing
protein kinase 1
Gene Summary
This gene encodes a protein
serine/threonine kinase that is activated when bound to the GTP-bound form of
Rho. The small GTPase Rho regulates formation of focal adhesions and stress
fibers of fibroblasts, as well as adhesion and aggregation of platelets and
lymphocytes by shuttling between the inactive GDP-bound form and the active
GTP-bound form. Rho is also essential in cytokinesis and plays a role in
transcriptional activation by serum response factor. This protein, a
downstream effector of Rho, phosphorylates and activates LIM kinase, which in
turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A
pseudogene, related to this gene, is also located on chromosome 18. [provided
by RefSeq, Aug 2015]
Hide
Cellular
Localizatio
Cell membrane, Cell projection,
Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane
Application
·
ICC/IF
Immunofluorescence
analysis of A549 cells using ROCK1 antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-ROCK1 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IF
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
ROCK1
Gene Synonyms
ROCK-I
P160ROCK
Gene Full Name
Rho associated coiled-coil containing
protein kinase 1
Gene Summary
This gene encodes a protein
serine/threonine kinase that is activated when bound to the GTP-bound form of
Rho. The small GTPase Rho regulates formation of focal adhesions and stress
fibers of fibroblasts, as well as adhesion and aggregation of platelets and
lymphocytes by shuttling between the inactive GDP-bound form and the active
GTP-bound form. Rho is also essential in cytokinesis and plays a role in
transcriptional activation by serum response factor. This protein, a
downstream effector of Rho, phosphorylates and activates LIM kinase, which in
turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A
pseudogene, related to this gene, is also located on chromosome 18. [provided
by RefSeq, Aug 2015]
Hide
Cellular
Localizatio
Cell membrane, Cell projection,
Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane
Application
·
ICC/IF
Immunofluorescence
analysis of A549 cells using ROCK1 antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-ROCK1 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IF
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
ROCK1
Gene Synonyms
ROCK-I
P160ROCK
Gene Full Name
Rho associated coiled-coil containing
protein kinase 1
Gene Summary
This gene encodes a protein
serine/threonine kinase that is activated when bound to the GTP-bound form of
Rho. The small GTPase Rho regulates formation of focal adhesions and stress
fibers of fibroblasts, as well as adhesion and aggregation of platelets and
lymphocytes by shuttling between the inactive GDP-bound form and the active
GTP-bound form. Rho is also essential in cytokinesis and plays a role in
transcriptional activation by serum response factor. This protein, a
downstream effector of Rho, phosphorylates and activates LIM kinase, which in
turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A
pseudogene, related to this gene, is also located on chromosome 18. [provided
by RefSeq, Aug 2015]
Hide
Cellular
Localizatio
Cell membrane, Cell projection,
Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane
Application
·
ICC/IF
Immunofluorescence
analysis of A549 cells using ROCK1 antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-ROCK1 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IF
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
ROCK1
Gene Synonyms
ROCK-I
P160ROCK
Gene Full Name
Rho associated coiled-coil containing
protein kinase 1
Gene Summary
This gene encodes a protein
serine/threonine kinase that is activated when bound to the GTP-bound form of
Rho. The small GTPase Rho regulates formation of focal adhesions and stress
fibers of fibroblasts, as well as adhesion and aggregation of platelets and
lymphocytes by shuttling between the inactive GDP-bound form and the active
GTP-bound form. Rho is also essential in cytokinesis and plays a role in
transcriptional activation by serum response factor. This protein, a
downstream effector of Rho, phosphorylates and activates LIM kinase, which in
turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A
pseudogene, related to this gene, is also located on chromosome 18. [provided
by RefSeq, Aug 2015]
Hide
Cellular
Localizatio
Cell membrane, Cell projection,
Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane
Application
·
ICC/IF
Immunofluorescence
analysis of A549 cells using ROCK1 antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-ROCK1 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IF
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
ROCK1
Gene Synonyms
ROCK-I
P160ROCK
Gene Full Name
Rho associated coiled-coil containing
protein kinase 1
Gene Summary
This gene encodes a protein
serine/threonine kinase that is activated when bound to the GTP-bound form of
Rho. The small GTPase Rho regulates formation of focal adhesions and stress
fibers of fibroblasts, as well as adhesion and aggregation of platelets and
lymphocytes by shuttling between the inactive GDP-bound form and the active
GTP-bound form. Rho is also essential in cytokinesis and plays a role in
transcriptional activation by serum response factor. This protein, a
downstream effector of Rho, phosphorylates and activates LIM kinase, which in
turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A
pseudogene, related to this gene, is also located on chromosome 18. [provided
by RefSeq, Aug 2015]
Hide
Cellular
Localizatio
Cell membrane, Cell projection,
Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane
Application
·
ICC/IF
Immunofluorescence
analysis of A549 cells using ROCK1 antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-ROCK1 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IF
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
ROCK1
Gene Synonyms
ROCK-I
P160ROCK
Gene Full Name
Rho associated coiled-coil containing
protein kinase 1
Gene Summary
This gene encodes a protein
serine/threonine kinase that is activated when bound to the GTP-bound form of
Rho. The small GTPase Rho regulates formation of focal adhesions and stress
fibers of fibroblasts, as well as adhesion and aggregation of platelets and
lymphocytes by shuttling between the inactive GDP-bound form and the active
GTP-bound form. Rho is also essential in cytokinesis and plays a role in
transcriptional activation by serum response factor. This protein, a
downstream effector of Rho, phosphorylates and activates LIM kinase, which in
turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A
pseudogene, related to this gene, is also located on chromosome 18. [provided
by RefSeq, Aug 2015]
Hide
Cellular
Localizatio
Cell membrane, Cell projection,
Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane
Application
·
ICC/IF
Immunofluorescence
analysis of A549 cells using ROCK1 antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-ROCK1 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IF
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
ROCK1
Gene Synonyms
ROCK-I
P160ROCK
Gene Full Name
Rho associated coiled-coil containing
protein kinase 1
Gene Summary
This gene encodes a protein
serine/threonine kinase that is activated when bound to the GTP-bound form of
Rho. The small GTPase Rho regulates formation of focal adhesions and stress
fibers of fibroblasts, as well as adhesion and aggregation of platelets and
lymphocytes by shuttling between the inactive GDP-bound form and the active
GTP-bound form. Rho is also essential in cytokinesis and plays a role in
transcriptional activation by serum response factor. This protein, a
downstream effector of Rho, phosphorylates and activates LIM kinase, which in
turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A
pseudogene, related to this gene, is also located on chromosome 18. [provided
by RefSeq, Aug 2015]
Hide
Cellular
Localizatio
Cell membrane, Cell projection,
Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane
Application
·
ICC/IF
Immunofluorescence
analysis of A549 cells using ROCK1 antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
|
Product Name |
Anti-ROCK1 antibody |
|
Antibody Type |
Primary Antibodies |
|
Immunogen |
Polypeptide |
Key Feature
|
Clonality |
Polyclonal |
|
Isotype |
IgG |
|
Host Species |
Rabbit |
|
Tested Application |
ELISAICC/IF |
|
ICC/IF:1:100-1:500 |
|
|
Species Reactivity |
HumanMouseRat |
|
Concentration |
1 mg/ml |
|
Purification |
Protein A |
Target Information
|
Gene Symbol |
ROCK1 |
|
Gene Synonyms |
ROCK-I |
|
Gene Full Name |
Rho associated coiled-coil containing protein kinase 1 |
|
Gene Summary |
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015] Hide |
|
Cellular Localizatio |
Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane |
Application
·
ICC/IF
Immunofluorescence analysis of A549 cells using ROCK1 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
|
Application Notes |
ICC/IF:1:100-1:500 |
Additional Information
|
Form |
Liquid |
|
Storage Instruction |
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
|
Storage Buffer |
Purified antibody in PBS with 0.05% sodium azide. |
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