Product Profile

Product Name	Anti-HIF-1beta antibody
Antibody Type	Primary Antibodies
Immunogen	Polypeptide

Key Feature

Clonality	Polyclonal
Isotype	IgG
Host Species	Rabbit
Tested Application	ELISAIHCWB
	WB:1:200-1:2000 IHC:1:200-1:1000
Species Reactivity	HumanMouseRat
Concentration	1 mg/ml
Purification	Protein A

Target Information

Gene Symbol	ARNT
Gene Synonyms	HIF1B TANGO bHLHe2 HIF1BETA HIF-1beta HIF1-beta HIF-1-beta Hide
Gene Full Name	aryl hydrocarbon receptor nuclear translocator
Gene Summary	This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013] Hide
Molecular Weight(MW)	87 kDa（Observed:45 kDa）
Cellular Localizatio	Nucleus

Application

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WB

Western blot analysis using HIF1 beta antibody against MCF-7(1) cell lysate.

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IHC

Immunohistochemical analysis of paraffin-embedded rectal cancer tissues using HIF1 beta antibody with DAB staining.

Application Notes

WB:1:200-1:2000 IHC:1:200-1:1000

Additional Information

Form	Liquid
Storage Instruction	Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer	Purified antibody in PBS with 0.05% sodium azide.