|
- 品牌：OminimAbs
- 产地：上海
- 型号：毫升
- 货号：OM641708
- 发布日期： 2024-08-30
- 更新日期： 2024-10-09
| 产地 | 上海 |
| 品牌 | OminimAbs |
| 保存条件 | |
| 货号 | OM641708 |
| 用途 | 实验研究 |
| 应用范围 | 科研实验 |
| 抗原来源 | 电询 |
| 保质期 | 2年 |
| 抗体名 | 电询 |
| 是否单克隆 | 否 |
| 克隆性 | 否 |
| 靶点 | 电询 |
| 适应物种 | 电询 |
| 形态 | 电询 |
| 宿主 | 电询 |
| 标记物 | 电询 |
| 包装规格 | 毫升 |
| 亚型 | 电询 |
| 标识物 | 电询 |
| 浓度 | 电询% |
| 免疫原 | 电询 |
| 是否进口 | 否 |
Product Profile
Product Name
Anti-TRAF2 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
TRAF2
Gene Synonyms
TRAP
TRAP3
RNF117
MGC:45012
Hide
Gene Full Name
TNF receptor associated factor 2
Gene Summary
The protein encoded by this gene is a
member of the TNF receptor associated factor (TRAF) protein family. TRAF
proteins associate with, and mediate the signal transduction from members of
the TNF receptor superfamily. This protein directly interacts with TNF
receptors, and forms a heterodimeric complex with TRAF1. This protein is
required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The
protein complex formed by this protein and TRAF1 interacts with the
inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the
anti-apoptotic signals from TNF receptors. The interaction of this protein
with TRADD, a TNF receptor associated apoptotic signal transducer, ensures
the recruitment of IAPs for the direct inhibition of caspase activation.
BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity,
can unbiquitinate and induce the degradation of this protein, and thus
potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript
variants have been found for this gene, but the biological validity of only
one transcript has been determined. [provided by RefSeq, Jul 2008]
Hide
Molecular
Weight(MW)
56 kDa
Cellular
Localizatio
Cytoplasm
Application
· 
WB
Western blot
analysis using TRAF2 antibody against A431(1), cell lysate.
· 
IHC
Immunohistochemical
analysis of paraffin-embedded colon cancer tissues using TRAF2 antibody with
DAB staining.
· 
ICC/IF
Immunofluorescence
analysis of MG-63 cells using TRAF2 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-TRAF2 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
TRAF2
Gene Synonyms
TRAP
TRAP3
RNF117
MGC:45012
Hide
Gene Full Name
TNF receptor associated factor 2
Gene Summary
The protein encoded by this gene is a
member of the TNF receptor associated factor (TRAF) protein family. TRAF
proteins associate with, and mediate the signal transduction from members of
the TNF receptor superfamily. This protein directly interacts with TNF
receptors, and forms a heterodimeric complex with TRAF1. This protein is
required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The
protein complex formed by this protein and TRAF1 interacts with the
inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the
anti-apoptotic signals from TNF receptors. The interaction of this protein
with TRADD, a TNF receptor associated apoptotic signal transducer, ensures
the recruitment of IAPs for the direct inhibition of caspase activation.
BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity,
can unbiquitinate and induce the degradation of this protein, and thus
potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript
variants have been found for this gene, but the biological validity of only
one transcript has been determined. [provided by RefSeq, Jul 2008]
Hide
Molecular
Weight(MW)
56 kDa
Cellular
Localizatio
Cytoplasm
Application
·
WB
Western blot
analysis using TRAF2 antibody against A431(1), cell lysate.
·
IHC
Immunohistochemical
analysis of paraffin-embedded colon cancer tissues using TRAF2 antibody with
DAB staining.
·
ICC/IF
Immunofluorescence
analysis of MG-63 cells using TRAF2 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-TRAF2 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
TRAF2
Gene Synonyms
TRAP
TRAP3
RNF117
MGC:45012
Hide
Gene Full Name
TNF receptor associated factor 2
Gene Summary
The protein encoded by this gene is a
member of the TNF receptor associated factor (TRAF) protein family. TRAF
proteins associate with, and mediate the signal transduction from members of
the TNF receptor superfamily. This protein directly interacts with TNF
receptors, and forms a heterodimeric complex with TRAF1. This protein is
required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The
protein complex formed by this protein and TRAF1 interacts with the
inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the
anti-apoptotic signals from TNF receptors. The interaction of this protein
with TRADD, a TNF receptor associated apoptotic signal transducer, ensures
the recruitment of IAPs for the direct inhibition of caspase activation.
BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity,
can unbiquitinate and induce the degradation of this protein, and thus
potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript
variants have been found for this gene, but the biological validity of only
one transcript has been determined. [provided by RefSeq, Jul 2008]
Hide
Molecular
Weight(MW)
56 kDa
Cellular
Localizatio
Cytoplasm
Application
·
WB
Western blot
analysis using TRAF2 antibody against A431(1), cell lysate.
·
IHC
Immunohistochemical
analysis of paraffin-embedded colon cancer tissues using TRAF2 antibody with
DAB staining.
·
ICC/IF
Immunofluorescence
analysis of MG-63 cells using TRAF2 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-TRAF2 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
TRAF2
Gene Synonyms
TRAP
TRAP3
RNF117
MGC:45012
Hide
Gene Full Name
TNF receptor associated factor 2
Gene Summary
The protein encoded by this gene is a
member of the TNF receptor associated factor (TRAF) protein family. TRAF
proteins associate with, and mediate the signal transduction from members of
the TNF receptor superfamily. This protein directly interacts with TNF
receptors, and forms a heterodimeric complex with TRAF1. This protein is
required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The
protein complex formed by this protein and TRAF1 interacts with the
inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the
anti-apoptotic signals from TNF receptors. The interaction of this protein
with TRADD, a TNF receptor associated apoptotic signal transducer, ensures
the recruitment of IAPs for the direct inhibition of caspase activation.
BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity,
can unbiquitinate and induce the degradation of this protein, and thus
potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript
variants have been found for this gene, but the biological validity of only
one transcript has been determined. [provided by RefSeq, Jul 2008]
Hide
Molecular
Weight(MW)
56 kDa
Cellular
Localizatio
Cytoplasm
Application
·
WB
Western blot
analysis using TRAF2 antibody against A431(1), cell lysate.
·
IHC
Immunohistochemical
analysis of paraffin-embedded colon cancer tissues using TRAF2 antibody with
DAB staining.
·
ICC/IF
Immunofluorescence
analysis of MG-63 cells using TRAF2 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-TRAF2 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
TRAF2
Gene Synonyms
TRAP
TRAP3
RNF117
MGC:45012
Hide
Gene Full Name
TNF receptor associated factor 2
Gene Summary
The protein encoded by this gene is a
member of the TNF receptor associated factor (TRAF) protein family. TRAF
proteins associate with, and mediate the signal transduction from members of
the TNF receptor superfamily. This protein directly interacts with TNF
receptors, and forms a heterodimeric complex with TRAF1. This protein is
required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The
protein complex formed by this protein and TRAF1 interacts with the
inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the
anti-apoptotic signals from TNF receptors. The interaction of this protein
with TRADD, a TNF receptor associated apoptotic signal transducer, ensures
the recruitment of IAPs for the direct inhibition of caspase activation.
BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity,
can unbiquitinate and induce the degradation of this protein, and thus
potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript
variants have been found for this gene, but the biological validity of only
one transcript has been determined. [provided by RefSeq, Jul 2008]
Hide
Molecular
Weight(MW)
56 kDa
Cellular
Localizatio
Cytoplasm
Application
·
WB
Western blot
analysis using TRAF2 antibody against A431(1), cell lysate.
·
IHC
Immunohistochemical
analysis of paraffin-embedded colon cancer tissues using TRAF2 antibody with
DAB staining.
·
ICC/IF
Immunofluorescence
analysis of MG-63 cells using TRAF2 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-TRAF2 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
TRAF2
Gene Synonyms
TRAP
TRAP3
RNF117
MGC:45012
Hide
Gene Full Name
TNF receptor associated factor 2
Gene Summary
The protein encoded by this gene is a
member of the TNF receptor associated factor (TRAF) protein family. TRAF
proteins associate with, and mediate the signal transduction from members of
the TNF receptor superfamily. This protein directly interacts with TNF
receptors, and forms a heterodimeric complex with TRAF1. This protein is
required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The
protein complex formed by this protein and TRAF1 interacts with the
inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the
anti-apoptotic signals from TNF receptors. The interaction of this protein
with TRADD, a TNF receptor associated apoptotic signal transducer, ensures
the recruitment of IAPs for the direct inhibition of caspase activation.
BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity,
can unbiquitinate and induce the degradation of this protein, and thus
potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript
variants have been found for this gene, but the biological validity of only
one transcript has been determined. [provided by RefSeq, Jul 2008]
Hide
Molecular
Weight(MW)
56 kDa
Cellular
Localizatio
Cytoplasm
Application
·
WB
Western blot
analysis using TRAF2 antibody against A431(1), cell lysate.
·
IHC
Immunohistochemical
analysis of paraffin-embedded colon cancer tissues using TRAF2 antibody with
DAB staining.
·
ICC/IF
Immunofluorescence
analysis of MG-63 cells using TRAF2 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-TRAF2 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
TRAF2
Gene Synonyms
TRAP
TRAP3
RNF117
MGC:45012
Hide
Gene Full Name
TNF receptor associated factor 2
Gene Summary
The protein encoded by this gene is a
member of the TNF receptor associated factor (TRAF) protein family. TRAF
proteins associate with, and mediate the signal transduction from members of
the TNF receptor superfamily. This protein directly interacts with TNF
receptors, and forms a heterodimeric complex with TRAF1. This protein is
required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The
protein complex formed by this protein and TRAF1 interacts with the
inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the
anti-apoptotic signals from TNF receptors. The interaction of this protein
with TRADD, a TNF receptor associated apoptotic signal transducer, ensures
the recruitment of IAPs for the direct inhibition of caspase activation.
BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity,
can unbiquitinate and induce the degradation of this protein, and thus
potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript
variants have been found for this gene, but the biological validity of only
one transcript has been determined. [provided by RefSeq, Jul 2008]
Hide
Molecular
Weight(MW)
56 kDa
Cellular
Localizatio
Cytoplasm
Application
·
WB
Western blot
analysis using TRAF2 antibody against A431(1), cell lysate.
·
IHC
Immunohistochemical
analysis of paraffin-embedded colon cancer tissues using TRAF2 antibody with
DAB staining.
·
ICC/IF
Immunofluorescence
analysis of MG-63 cells using TRAF2 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-TRAF2 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
TRAF2
Gene Synonyms
TRAP
TRAP3
RNF117
MGC:45012
Hide
Gene Full Name
TNF receptor associated factor 2
Gene Summary
The protein encoded by this gene is a
member of the TNF receptor associated factor (TRAF) protein family. TRAF
proteins associate with, and mediate the signal transduction from members of
the TNF receptor superfamily. This protein directly interacts with TNF
receptors, and forms a heterodimeric complex with TRAF1. This protein is
required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The
protein complex formed by this protein and TRAF1 interacts with the
inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the
anti-apoptotic signals from TNF receptors. The interaction of this protein
with TRADD, a TNF receptor associated apoptotic signal transducer, ensures
the recruitment of IAPs for the direct inhibition of caspase activation.
BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity,
can unbiquitinate and induce the degradation of this protein, and thus
potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript
variants have been found for this gene, but the biological validity of only
one transcript has been determined. [provided by RefSeq, Jul 2008]
Hide
Molecular
Weight(MW)
56 kDa
Cellular
Localizatio
Cytoplasm
Application
·
WB
Western blot
analysis using TRAF2 antibody against A431(1), cell lysate.
·
IHC
Immunohistochemical
analysis of paraffin-embedded colon cancer tissues using TRAF2 antibody with
DAB staining.
·
ICC/IF
Immunofluorescence
analysis of MG-63 cells using TRAF2 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-TRAF2 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
TRAF2
Gene Synonyms
TRAP
TRAP3
RNF117
MGC:45012
Hide
Gene Full Name
TNF receptor associated factor 2
Gene Summary
The protein encoded by this gene is a
member of the TNF receptor associated factor (TRAF) protein family. TRAF
proteins associate with, and mediate the signal transduction from members of
the TNF receptor superfamily. This protein directly interacts with TNF
receptors, and forms a heterodimeric complex with TRAF1. This protein is
required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The
protein complex formed by this protein and TRAF1 interacts with the
inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the
anti-apoptotic signals from TNF receptors. The interaction of this protein
with TRADD, a TNF receptor associated apoptotic signal transducer, ensures
the recruitment of IAPs for the direct inhibition of caspase activation.
BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity,
can unbiquitinate and induce the degradation of this protein, and thus
potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript
variants have been found for this gene, but the biological validity of only
one transcript has been determined. [provided by RefSeq, Jul 2008]
Hide
Molecular
Weight(MW)
56 kDa
Cellular
Localizatio
Cytoplasm
Application
·
WB
Western blot
analysis using TRAF2 antibody against A431(1), cell lysate.
·
IHC
Immunohistochemical
analysis of paraffin-embedded colon cancer tissues using TRAF2 antibody with
DAB staining.
·
ICC/IF
Immunofluorescence
analysis of MG-63 cells using TRAF2 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-TRAF2 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
TRAF2
Gene Synonyms
TRAP
Hide
Gene Full Name
TNF receptor associated factor 2
Gene Summary
The protein encoded by this gene is a
member of the TNF receptor associated factor (TRAF) protein family. TRAF
proteins associate with, and mediate the signal transduction from members of
the TNF receptor superfamily. This protein directly interacts with TNF
receptors, and forms a heterodimeric complex with TRAF1. This protein is
required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The
protein complex formed by this protein and TRAF1 interacts with the
inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the
anti-apoptotic signals from TNF receptors. The interaction of this protein
with TRADD, a TNF receptor associated apoptotic signal transducer, ensures
the recruitment of IAPs for the direct inhibition of caspase activation.
BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity,
can unbiquitinate and induce the degradation of this protein, and thus
potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript
variants have been found for this gene, but the biological validity of only
one transcript has been determined. [provided by RefSeq, Jul 2008]
Hide
Molecular
Weight(MW)
56 kDa
Cellular
Localizatio
Cytoplasm
Application
IHC:1:200-1:1000
ICC/IF:1:100-1:500
TRAP3
RNF117
MGC:45012
·
WB
Western blot analysis using TRAF2 antibody against A431(1), cell lysate.
·
IHC
Immunohistochemical analysis of paraffin-embedded colon cancer tissues using TRAF2 antibody with DAB staining.
·
ICC/IF
Immunofluorescence analysis of MG-63 cells using TRAF2 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
|
Application Notes |
WB:1:200-1:2000 |
Additional Information
|
Form |
Liquid |
|
Storage Instruction |
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
|
Storage Buffer |
Purified antibody in PBS with 0.05% sodium azide. |
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