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产地 | 上海 |
品牌 | OminimAbs |
保存条件 | |
货号 | OM641708 |
用途 | 实验研究 |
应用范围 | 科研实验 |
抗原来源 | 电询 |
保质期 | 2年 |
抗体名 | 电询 |
是否单克隆 | 否 |
克隆性 | 否 |
靶点 | 电询 |
适应物种 | 电询 |
形态 | 电询 |
宿主 | 电询 |
标记物 | 电询 |
包装规格 | 毫升 |
亚型 | 电询 |
标识物 | 电询 |
浓度 | 电询% |
免疫原 | 电询 |
是否进口 | 否 |
Product Profile
Product Name
Anti-GluR2 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IF
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
GRIA2
Gene Synonyms
GLUR2
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Gene Full Name
glutamate ionotropic receptor AMPA type
subunit 2
Gene Summary
Glutamate receptors are the predominant
excitatory neurotransmitter receptors in the mammalian brain and are
activated in a variety of normal neurophysiologic processes. This gene
product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole
propionate (AMPA), and function as ligand-activated cation channels. These
channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded
by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within
the second transmembrane domain, which is thought to render the channel
impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing
is essential for brain function, and defective GRIA2 RNA editing at the Q/R
site may be relevant to amyotrophic lateral sclerosis (ALS) etiology.
Alternative splicing, resulting in transcript variants encoding different
isoforms, (including the flip and flop isoforms that vary in their signal
transduction properties), has been noted for this gene. [provided by RefSeq,
Jul 2008]
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Cellular
Localizatio
Cell membrane, postsynaptic cell
membrane, postsynaptic density membrane, endoplasmic reticulum membrane
Application
GLURB
GluA2
HBGR2
NEDLIB
gluR-2
gluR-B
GluR-K2
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ICC/IF
Immunofluorescence analysis of Hela cells using GluR2 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application Notes |
ICC/IF:1:100-1:500 |
Additional Information
Form |
Liquid |
Storage Instruction |
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
Storage Buffer |
Purified antibody in PBS with 0.05% sodium azide |