|
- 品牌：OminimAbs
- 产地：上海
- 型号：毫升
- 货号：OM641708
- 发布日期： 2024-08-29
- 更新日期： 2024-10-09
| 产地 | 上海 |
| 品牌 | OminimAbs |
| 保存条件 | |
| 货号 | OM641708 |
| 用途 | 实验研究 |
| 应用范围 | 科研实验 |
| 抗原来源 | 电询 |
| 保质期 | 2年 |
| 抗体名 | 电询 |
| 是否单克隆 | 否 |
| 克隆性 | 否 |
| 靶点 | 电询 |
| 适应物种 | 电询 |
| 形态 | 电询 |
| 宿主 | 电询 |
| 标记物 | 电询 |
| 包装规格 | 毫升 |
| 亚型 | 电询 |
| 标识物 | 电询 |
| 浓度 | 电询% |
| 免疫原 | 电询 |
| 是否进口 | 否 |
Product Profile
Product Name
Anti-TTR antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
TTR
Gene Synonyms
CTS
TTN
ATTR
CTS1
PALB
TBPA
HEL111
HsT2651
Hide
Gene Full Name
transthyretin
Gene Summary
This gene encodes one of the three
prealbumins, which include alpha-1-antitrypsin, transthyretin and
orosomucoid. The encoded protein, transthyretin, is a homo-tetrameric carrier
protein, which transports thyroid hormones in the plasma and cerebrospinal fluid.
It is also involved in the transport of retinol (vitamin A) in the plasma by
associating with retinol-binding protein. The protein may also be involved in
other intracellular processes including proteolysis, nerve regeneration,
autophagy and glucose homeostasis. Mutations in this gene are associated with
amyloid deposition, predominantly affecting peripheral nerves or the heart,
while a small percentage of the gene mutations are non-amyloidogenic. The
mutations are implicated in the etiology of several diseases, including
amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic
vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis,
meningocerebrovascular amyloidosis and carpal tunnel syndrome. [provided by
RefSeq, Aug 2017]
Hide
Molecular
Weight(MW)
16 kDa
Cellular
Localizatio
Amyloid, Cytoplasm, Secreted
Application
·
WB
Western blot
analysis using TTR antibody against MCF-7(1), COS-7(2) cell lysate.
·
IHC
Immunohistochemical
analysis of paraffin-embedded lung cancer tissues using TTR antibody with DAB
staining.
·
ICC/IF
Immunofluorescence
analysis of Hela cells using TTR antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-TTR antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
TTR
Gene Synonyms
CTS
TTN
ATTR
CTS1
PALB
TBPA
HEL111
HsT2651
Hide
Gene Full Name
transthyretin
Gene Summary
This gene encodes one of the three
prealbumins, which include alpha-1-antitrypsin, transthyretin and
orosomucoid. The encoded protein, transthyretin, is a homo-tetrameric carrier
protein, which transports thyroid hormones in the plasma and cerebrospinal fluid.
It is also involved in the transport of retinol (vitamin A) in the plasma by
associating with retinol-binding protein. The protein may also be involved in
other intracellular processes including proteolysis, nerve regeneration,
autophagy and glucose homeostasis. Mutations in this gene are associated with
amyloid deposition, predominantly affecting peripheral nerves or the heart,
while a small percentage of the gene mutations are non-amyloidogenic. The
mutations are implicated in the etiology of several diseases, including
amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic
vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis,
meningocerebrovascular amyloidosis and carpal tunnel syndrome. [provided by
RefSeq, Aug 2017]
Hide
Molecular
Weight(MW)
16 kDa
Cellular
Localizatio
Amyloid, Cytoplasm, Secreted
Application
·
WB
Western blot
analysis using TTR antibody against MCF-7(1), COS-7(2) cell lysate.
·
IHC
Immunohistochemical
analysis of paraffin-embedded lung cancer tissues using TTR antibody with DAB
staining.
·
ICC/IF
Immunofluorescence
analysis of Hela cells using TTR antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-TTR antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
TTR
Gene Synonyms
CTS
TTN
ATTR
CTS1
PALB
TBPA
HEL111
HsT2651
Hide
Gene Full Name
transthyretin
Gene Summary
This gene encodes one of the three
prealbumins, which include alpha-1-antitrypsin, transthyretin and
orosomucoid. The encoded protein, transthyretin, is a homo-tetrameric carrier
protein, which transports thyroid hormones in the plasma and cerebrospinal fluid.
It is also involved in the transport of retinol (vitamin A) in the plasma by
associating with retinol-binding protein. The protein may also be involved in
other intracellular processes including proteolysis, nerve regeneration,
autophagy and glucose homeostasis. Mutations in this gene are associated with
amyloid deposition, predominantly affecting peripheral nerves or the heart,
while a small percentage of the gene mutations are non-amyloidogenic. The
mutations are implicated in the etiology of several diseases, including
amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic
vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis,
meningocerebrovascular amyloidosis and carpal tunnel syndrome. [provided by
RefSeq, Aug 2017]
Hide
Molecular
Weight(MW)
16 kDa
Cellular
Localizatio
Amyloid, Cytoplasm, Secreted
Application
·
WB
Western blot
analysis using TTR antibody against MCF-7(1), COS-7(2) cell lysate.
·
IHC
Immunohistochemical
analysis of paraffin-embedded lung cancer tissues using TTR antibody with DAB
staining.
·
ICC/IF
Immunofluorescence
analysis of Hela cells using TTR antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-TTR antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
TTR
Gene Synonyms
CTS
TTN
ATTR
CTS1
PALB
TBPA
HEL111
HsT2651
Hide
Gene Full Name
transthyretin
Gene Summary
This gene encodes one of the three
prealbumins, which include alpha-1-antitrypsin, transthyretin and
orosomucoid. The encoded protein, transthyretin, is a homo-tetrameric carrier
protein, which transports thyroid hormones in the plasma and cerebrospinal fluid.
It is also involved in the transport of retinol (vitamin A) in the plasma by
associating with retinol-binding protein. The protein may also be involved in
other intracellular processes including proteolysis, nerve regeneration,
autophagy and glucose homeostasis. Mutations in this gene are associated with
amyloid deposition, predominantly affecting peripheral nerves or the heart,
while a small percentage of the gene mutations are non-amyloidogenic. The
mutations are implicated in the etiology of several diseases, including
amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic
vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis,
meningocerebrovascular amyloidosis and carpal tunnel syndrome. [provided by
RefSeq, Aug 2017]
Hide
Molecular
Weight(MW)
16 kDa
Cellular
Localizatio
Amyloid, Cytoplasm, Secreted
Application
·
WB
Western blot
analysis using TTR antibody against MCF-7(1), COS-7(2) cell lysate.
·
IHC
Immunohistochemical
analysis of paraffin-embedded lung cancer tissues using TTR antibody with DAB
staining.
·
ICC/IF
Immunofluorescence
analysis of Hela cells using TTR antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-TTR antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
TTR
Gene Synonyms
CTS
TTN
ATTR
CTS1
PALB
TBPA
HEL111
HsT2651
Hide
Gene Full Name
transthyretin
Gene Summary
This gene encodes one of the three
prealbumins, which include alpha-1-antitrypsin, transthyretin and
orosomucoid. The encoded protein, transthyretin, is a homo-tetrameric carrier
protein, which transports thyroid hormones in the plasma and cerebrospinal fluid.
It is also involved in the transport of retinol (vitamin A) in the plasma by
associating with retinol-binding protein. The protein may also be involved in
other intracellular processes including proteolysis, nerve regeneration,
autophagy and glucose homeostasis. Mutations in this gene are associated with
amyloid deposition, predominantly affecting peripheral nerves or the heart,
while a small percentage of the gene mutations are non-amyloidogenic. The
mutations are implicated in the etiology of several diseases, including
amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic
vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis,
meningocerebrovascular amyloidosis and carpal tunnel syndrome. [provided by
RefSeq, Aug 2017]
Hide
Molecular
Weight(MW)
16 kDa
Cellular
Localizatio
Amyloid, Cytoplasm, Secreted
Application
·
WB
Western blot
analysis using TTR antibody against MCF-7(1), COS-7(2) cell lysate.
·
IHC
Immunohistochemical
analysis of paraffin-embedded lung cancer tissues using TTR antibody with DAB
staining.
·
ICC/IF
Immunofluorescence
analysis of Hela cells using TTR antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-TTR antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
TTR
Gene Synonyms
CTS
TTN
ATTR
CTS1
PALB
TBPA
HEL111
HsT2651
Hide
Gene Full Name
transthyretin
Gene Summary
This gene encodes one of the three
prealbumins, which include alpha-1-antitrypsin, transthyretin and
orosomucoid. The encoded protein, transthyretin, is a homo-tetrameric carrier
protein, which transports thyroid hormones in the plasma and cerebrospinal fluid.
It is also involved in the transport of retinol (vitamin A) in the plasma by
associating with retinol-binding protein. The protein may also be involved in
other intracellular processes including proteolysis, nerve regeneration,
autophagy and glucose homeostasis. Mutations in this gene are associated with
amyloid deposition, predominantly affecting peripheral nerves or the heart,
while a small percentage of the gene mutations are non-amyloidogenic. The
mutations are implicated in the etiology of several diseases, including
amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic
vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis,
meningocerebrovascular amyloidosis and carpal tunnel syndrome. [provided by
RefSeq, Aug 2017]
Hide
Molecular
Weight(MW)
16 kDa
Cellular
Localizatio
Amyloid, Cytoplasm, Secreted
Application
·
WB
Western blot
analysis using TTR antibody against MCF-7(1), COS-7(2) cell lysate.
·
IHC
Immunohistochemical
analysis of paraffin-embedded lung cancer tissues using TTR antibody with DAB
staining.
·
ICC/IF
Immunofluorescence
analysis of Hela cells using TTR antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-TTR antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
TTR
Gene Synonyms
CTS
TTN
ATTR
CTS1
PALB
TBPA
HEL111
HsT2651
Hide
Gene Full Name
transthyretin
Gene Summary
This gene encodes one of the three
prealbumins, which include alpha-1-antitrypsin, transthyretin and
orosomucoid. The encoded protein, transthyretin, is a homo-tetrameric carrier
protein, which transports thyroid hormones in the plasma and cerebrospinal fluid.
It is also involved in the transport of retinol (vitamin A) in the plasma by
associating with retinol-binding protein. The protein may also be involved in
other intracellular processes including proteolysis, nerve regeneration,
autophagy and glucose homeostasis. Mutations in this gene are associated with
amyloid deposition, predominantly affecting peripheral nerves or the heart,
while a small percentage of the gene mutations are non-amyloidogenic. The
mutations are implicated in the etiology of several diseases, including
amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic
vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis,
meningocerebrovascular amyloidosis and carpal tunnel syndrome. [provided by
RefSeq, Aug 2017]
Hide
Molecular
Weight(MW)
16 kDa
Cellular
Localizatio
Amyloid, Cytoplasm, Secreted
Application
·
WB
Western blot
analysis using TTR antibody against MCF-7(1), COS-7(2) cell lysate.
·
IHC
Immunohistochemical
analysis of paraffin-embedded lung cancer tissues using TTR antibody with DAB
staining.
·
ICC/IF
Immunofluorescence
analysis of Hela cells using TTR antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-TTR antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
TTR
Gene Synonyms
CTS
TTN
ATTR
CTS1
PALB
TBPA
HEL111
HsT2651
Hide
Gene Full Name
transthyretin
Gene Summary
This gene encodes one of the three
prealbumins, which include alpha-1-antitrypsin, transthyretin and
orosomucoid. The encoded protein, transthyretin, is a homo-tetrameric carrier
protein, which transports thyroid hormones in the plasma and cerebrospinal fluid.
It is also involved in the transport of retinol (vitamin A) in the plasma by
associating with retinol-binding protein. The protein may also be involved in
other intracellular processes including proteolysis, nerve regeneration,
autophagy and glucose homeostasis. Mutations in this gene are associated with
amyloid deposition, predominantly affecting peripheral nerves or the heart,
while a small percentage of the gene mutations are non-amyloidogenic. The
mutations are implicated in the etiology of several diseases, including
amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic
vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis,
meningocerebrovascular amyloidosis and carpal tunnel syndrome. [provided by
RefSeq, Aug 2017]
Hide
Molecular
Weight(MW)
16 kDa
Cellular
Localizatio
Amyloid, Cytoplasm, Secreted
Application
·
WB
Western blot
analysis using TTR antibody against MCF-7(1), COS-7(2) cell lysate.
·
IHC
Immunohistochemical
analysis of paraffin-embedded lung cancer tissues using TTR antibody with DAB
staining.
·
ICC/IF
Immunofluorescence
analysis of Hela cells using TTR antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-TTR antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
TTR
Gene Synonyms
CTS
TTN
ATTR
CTS1
PALB
TBPA
HEL111
HsT2651
Hide
Gene Full Name
transthyretin
Gene Summary
This gene encodes one of the three
prealbumins, which include alpha-1-antitrypsin, transthyretin and
orosomucoid. The encoded protein, transthyretin, is a homo-tetrameric carrier
protein, which transports thyroid hormones in the plasma and cerebrospinal fluid.
It is also involved in the transport of retinol (vitamin A) in the plasma by
associating with retinol-binding protein. The protein may also be involved in
other intracellular processes including proteolysis, nerve regeneration,
autophagy and glucose homeostasis. Mutations in this gene are associated with
amyloid deposition, predominantly affecting peripheral nerves or the heart,
while a small percentage of the gene mutations are non-amyloidogenic. The
mutations are implicated in the etiology of several diseases, including
amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic
vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis,
meningocerebrovascular amyloidosis and carpal tunnel syndrome. [provided by
RefSeq, Aug 2017]
Hide
Molecular
Weight(MW)
16 kDa
Cellular
Localizatio
Amyloid, Cytoplasm, Secreted
Application
·
WB
Western blot
analysis using TTR antibody against MCF-7(1), COS-7(2) cell lysate.
·
IHC
Immunohistochemical
analysis of paraffin-embedded lung cancer tissues using TTR antibody with DAB
staining.
·
ICC/IF
Immunofluorescence
analysis of Hela cells using TTR antibody (green). Blue: DAPI fluorescent DNA
dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application
Notes
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-TTR antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
TTR
Gene Synonyms
CTS
Hide
Gene Full Name
transthyretin
Gene Summary
This gene encodes one of the three
prealbumins, which include alpha-1-antitrypsin, transthyretin and
orosomucoid. The encoded protein, transthyretin, is a homo-tetrameric carrier
protein, which transports thyroid hormones in the plasma and cerebrospinal fluid.
It is also involved in the transport of retinol (vitamin A) in the plasma by
associating with retinol-binding protein. The protein may also be involved in
other intracellular processes including proteolysis, nerve regeneration,
autophagy and glucose homeostasis. Mutations in this gene are associated with
amyloid deposition, predominantly affecting peripheral nerves or the heart,
while a small percentage of the gene mutations are non-amyloidogenic. The
mutations are implicated in the etiology of several diseases, including
amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic
vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis,
meningocerebrovascular amyloidosis and carpal tunnel syndrome. [provided by
RefSeq, Aug 2017]
Hide
Molecular
Weight(MW)
16 kDa
Cellular
Localizatio
Amyloid, Cytoplasm, Secreted
Application
IHC:1:200-1:1000
ICC/IF:1:100-1:500
TTN
ATTR
CTS1
PALB
TBPA
HEL111
HsT2651
·
WB
Western blot analysis using TTR antibody against MCF-7(1), COS-7(2) cell lysate.
·
IHC
Immunohistochemical analysis of paraffin-embedded lung cancer tissues using TTR antibody with DAB staining.
·
ICC/IF
Immunofluorescence analysis of Hela cells using TTR antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
|
Application Notes |
WB:1:200-1:2000 |
Additional Information
|
Form |
Liquid |
|
Storage Instruction |
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
|
Storage Buffer |
Purified antibody in PBS with 0.05% sodium azide. |
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