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产地 | 上海 |
品牌 | OminimAbs |
保存条件 | |
货号 | OM642132 |
用途 | 实验研究 |
应用范围 | 科研实验 |
抗原来源 | 电询 |
保质期 | 2年 |
抗体名 | 电询 |
是否单克隆 | 否 |
克隆性 | 否 |
靶点 | 电询 |
适应物种 | 电询 |
形态 | 电询 |
宿主 | 电询 |
标记物 | 电询 |
包装规格 | 毫升 |
亚型 | 电询 |
标识物 | 电询 |
浓度 | 电询% |
免疫原 | 电询 |
是否进口 | 否 |
Product Profile
Product Name
Anti-ER-alpha antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
ESR1
Gene Synonyms
ER
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Gene Full Name
estrogen receptor 1
Gene Summary
This gene encodes an estrogen receptor
and ligand-activated transcription factor. The canonical protein contains an
N-terminal ligand-independent transactivation domain, a central DNA binding
domain, a hinge domain, and a C-terminal ligand-dependent transactivation
domain. The protein localizes to the nucleus where it may form either a
homodimer or a heterodimer with estrogen receptor 2. The protein encoded by
this gene regulates the transcription of many estrogen-inducible genes that
play a role in growth, metabolism, sexual development, gestation, and other
reproductive functions and is expressed in many non-reproductive tissues. The
receptor encoded by this gene plays a key role in breast cancer, endometrial
cancer, and osteoporosis. This gene is reported to have dozens of transcript
variants due to the use of alternate promoters and alternative splicing,
however, the full-length nature of many of these variants remain uncertain.
[provided by RefSeq, Jul 2020]
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Molecular
Weight(MW)
66 kDa
Source
Rabbit
Cellular
Localizatio
Nucleus. Cytoplasm. Cell membrane.
Application
IHC:1:200-1:1000
ICC/IF:1:100-1:500
ESR
Era
ESRA
ESTRR
NR3A1
·
WB
Western blot analysis using ER alpha antibody against Raji(1), Jurkat(2), HepG2(3) cell lysate.
·
IHC
Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using ER alpha antibody with DAB staining.
·
ICC/IF
Immunofluorescence analysis of MG-63 cells using ER alpha antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application Notes |
WB:1:200-1:2000 |
Additional Information
Form |
Liquid |
Storage Instruction |
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
Storage Buffer |
Purified antibody in PBS with 0.05% sodium azide. |