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产地 | 上海 |
品牌 | OminimAbs |
保存条件 | |
货号 | OM642132 |
用途 | 实验研究 |
应用范围 | 科研实验 |
抗原来源 | 电询 |
保质期 | 2年 |
抗体名 | 电询 |
是否单克隆 | 否 |
克隆性 | 否 |
靶点 | 电询 |
适应物种 | 电询 |
形态 | 电询 |
宿主 | 电询 |
标记物 | 电询 |
包装规格 | 毫升 |
亚型 | 电询 |
标识物 | 电询 |
浓度 | 电询% |
免疫原 | 电询 |
是否进口 | 否 |
Product Profile
Product Name
Anti-p21 Cip1 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHC
IHC:1:200-1:1000
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
CDKN1A
Gene Synonyms
P21
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Gene Full Name
cyclin dependent kinase inhibitor 1A
Gene Summary
This gene encodes a potent
cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits
the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4
complexes, and thus functions as a regulator of cell cycle progression at G1.
The expression of this gene is tightly controlled by the tumor suppressor
protein p53, through which this protein mediates the p53-dependent cell cycle
G1 phase arrest in response to a variety of stress stimuli. This protein can
interact with proliferating cell nuclear antigen, a DNA polymerase accessory
factor, and plays a regulatory role in S phase DNA replication and DNA damage
repair. This protein was reported to be specifically cleaved by CASP3-like
caspases, which thus leads to a dramatic activation of cyclin-dependent
kinase2, and may be instrumental in the execution of apoptosis following
caspase activation. Mice that lack this gene have the ability to regenerate
damaged or missing tissue. Multiple alternatively spliced variants have been
found for this gene. [provided by RefSeq, Sep 2015]
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Source
Rabbit
Cellular
Localizatio
Cytoplasm, Nucleus
Application
ICC/IF:1:100-1:500
CIP1
SDI1
WAF1
CAP20
CDKN1
MDA-6
p21CIP1
·
IHC
Immunohistochemical analysis of paraffin-embedded ovarian cance tissues using p21 Cip1 antibody with DAB staining.
·
ICC/IF
Immunofluorescence analysis of Hela cells using p21 Cip1 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application Notes |
IHC:1:200-1:1000 |
Additional Information
Form |
Liquid |
Storage Instruction |
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
Storage Buffer |
Purified antibody in PBS with 0.05% sodium azide. |