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产地 | 上海 |
品牌 | OminimAbs |
保存条件 | |
货号 | OM641708 |
用途 | 实验研究 |
应用范围 | 科研实验 |
抗原来源 | 电询 |
保质期 | 2年 |
抗体名 | 电询 |
是否单克隆 | 否 |
克隆性 | 否 |
靶点 | 电询 |
适应物种 | 电询 |
形态 | 电询 |
宿主 | 电询 |
标记物 | 电询 |
包装规格 | 毫升 |
亚型 | 电询 |
标识物 | 电询 |
浓度 | 电询% |
免疫原 | 电询 |
是否进口 | 否 |
Product Profile
Product Name
Anti-stat3 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
STAT3
Gene Synonyms
APRF
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Gene Full Name
signal transducer and activator of
transcription 3
Gene Summary
The protein encoded by this gene is a
member of the STAT protein family. In response to cytokines and growth
factors, STAT family members are phosphorylated by the receptor associated
kinases, and then form homo- or heterodimers that translocate to the cell
nucleus where they act as transcription activators. This protein is activated
through phosphorylation in response to various cytokines and growth factors
including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the
expression of a variety of genes in response to cell stimuli, and thus plays
a key role in many cellular processes such as cell growth and apoptosis. The
small GTPase Rac1 has been shown to bind and regulate the activity of this
protein. PIAS3 protein is a specific inhibitor of this protein. This gene
also plays a role in regulating host response to viral and bacterial
infections. Mutations in this gene are associated with infantile-onset
multisystem autoimmune disease and hyper-immunoglobulin E syndrome. [provided
by RefSeq, Aug 2020]
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Molecular
Weight(MW)
88 kDa(Observed:68
kDa)
Source
Rabbit
Cellular
Localizatio
Cytoplasm, Nucleus
Application
IHC:1:200-1:1000
ICC/IF:1:100-1:500
HIES
ADMIO
ADMIO1
·
WB
Western blot analysis using stat3 antibody against Raji(1), MCF-7(2), Jurkat(3), HepG2(4) cell lysate.
·
IHC
Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using stat3 antibody with DAB staining.
·
ICC/IF
Immunofluorescence analysis of A549 cells using stat3 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application Notes |
WB:1:200-1:2000 |
Additional Information
Form |
Liquid |
Storage Instruction |
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
Storage Buffer |
Purified antibody in PBS with 0.05% sodium azide. |