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产地 | 上海 |
品牌 | OminimAbs |
保存条件 | |
货号 | 电询 |
用途 | 实验研究 |
应用范围 | 科研实验 |
抗原来源 | 电询 |
保质期 | 2年 |
抗体名 | 电询 |
是否单克隆 | |
克隆性 | 否 |
靶点 | 电询 |
适应物种 | 电询 |
形态 | 电询 |
宿主 | 电询 |
标记物 | 电询 |
包装规格 | 毫升 |
亚型 | 电询 |
标识物 | 电询 |
浓度 | 电询% |
免疫原 | 电询 |
是否进口 | 否 |
Product Profile
Product Name
Anti-CyclinE1 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAIHCWB
WB:1:200-1:2000
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
CCNE1
Gene Synonyms
CCNE1
Gene Full Name
cyclin E1
Gene Summary
The protein encoded by this gene belongs
to the highly conserved cyclin family, whose members are characterized by a
dramatic periodicity in protein abundance through the cell cycle. Cyclins
function as regulators of CDK kinases. Different cyclins exhibit distinct
expression and degradation patterns which contribute to the temporal
coordination of each mitotic event. This cyclin forms a complex with and
functions as a regulatory subunit of CDK2, whose activity is required for
cell cycle G1/S transition. This protein accumulates at the G1-S phase
boundary and is degraded as cells progress through S phase. Overexpression of
this gene has been observed in many tumors, which results in chromosome
instability, and thus may contribute to tumorigenesis. This protein was found
to associate with, and be involved in, the phosphorylation of NPAT protein
(nuclear protein mapped to the ATM locus), which participates in cell-cycle
regulated histone gene expression and plays a critical role in promoting
cell-cycle progression in the absence of pRB. [provided by RefSeq, Apr 2016]
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Molecular
Weight(MW)
47KDa
Source
Rabbit
Cellular
Localizatio
Nucleus
Application
IHC:1:200-1:1000
CCNE
pCCNE1
·
WB
Western blot analysis using CyclinE1 antibody against COS-7 (1), A549 (2), K562 (3) cell lysate.
·
IHC
Immunohistochemical analysis of paraffin-embedded lung cancer tissues using CyclinE1 antibody with DAB staining.
Application Notes |
WB:1:200-1:2000 |
Additional Information
Form |
Liquid |
Storage Instruction |
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
Storage Buffer |
Purified antibody in PBS with 0.05% sodium azide. |