![]() |
产地 | 上海 |
品牌 | OminimAbs |
保存条件 | |
货号 | OM641708 |
用途 | 实验研究 |
应用范围 | 科研实验 |
抗原来源 | 电询 |
保质期 | 2年 |
抗体名 | 电询 |
是否单克隆 | 否 |
克隆性 | 否 |
靶点 | 电询 |
适应物种 | 电询 |
形态 | 电询 |
宿主 | 电询 |
标记物 | 电询 |
包装规格 | 毫升 |
亚型 | 电询 |
标识物 | 电询 |
浓度 | 电询% |
免疫原 | 电询 |
是否进口 | 否 |
Product Profile
Product Name
Anti-DUSP6 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
DUSP6
Gene Synonyms
DUS6
Hide
Gene Full Name
dual specificity phosphatase 6
Gene Summary
The protein encoded by this gene is a
member of the dual specificity protein phosphatase subfamily. These
phosphatases inactivate their target kinases by dephosphorylating both the
phosphoserine/threonine and phosphotyrosine residues. They negatively
regulate members of the mitogen-activated protein (MAP) kinase superfamily
(MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation
and differentiation. Different members of the family of dual specificity
phosphatases show distinct substrate specificities for various MAP kinases,
different tissue distribution and subcellular localization, and different
modes of inducibility of their expression by extracellular stimuli. This gene
product inactivates ERK2, is expressed in a variety of tissues with the
highest levels in heart and pancreas, and unlike most other members of this
family, is localized in the cytoplasm. Mutations in this gene have been
associated with congenital hypogonadotropic hypogonadism. Alternatively
spliced transcript variants have been found for this gene. [provided by
RefSeq, Jan 2014]
Hide
Molecular
Weight(MW)
42 kDa, 26kDa
Source
Rabbit
Cellular
Localizatio
Cytoplasm
Application
IHC:1:200-1:1000
ICC/IF:1:100-1:500
HH19
MKP3
PYST1
·
WB
Western blot analysis using DUSP6 antibody against CACO2 (1), HUVEC (2), HepG2 (3), MCF-7 (4) cell lysate.
·
IHC
Immunohistochemical analysis of paraffin-embedded lung cancer tissues using DUSP6 antibody with DAB staining.
·
ICC/IF
Immunofluorescence analysis of Hela cells using DUSP6 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application Notes |
WB:1:200-1:2000 |
Additional Information
Form |
Liquid |
Storage Instruction |
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
Storage Buffer |
Purified antibody in PBS with 0.05% sodium azide. |