|
- 品牌：OminimAbs
- 产地：上海
- 型号：毫升
- 货号：OM641708
- 发布日期： 2024-08-23
- 更新日期： 2024-10-09
| 产地 | 上海 |
| 品牌 | OminimAbs |
| 保存条件 | |
| 货号 | OM641708 |
| 用途 | 实验研究 |
| 应用范围 | 科研实验 |
| 抗原来源 | 电询 |
| 保质期 | 2年 |
| 抗体名 | 电询 |
| 是否单克隆 | 否 |
| 克隆性 | 否 |
| 靶点 | 电询 |
| 适应物种 | 电询 |
| 形态 | 电询 |
| 宿主 | 电询 |
| 标记物 | 电询 |
| 包装规格 | 毫升 |
| 亚型 | 电询 |
| 标识物 | 电询 |
| 浓度 | 电询% |
| 免疫原 | 电询 |
| 是否进口 | 否 |
Product Profile
Product Name
Anti-TNFSF11 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
TNFSF11
Gene Synonyms
TNF11
ODF
OPGL
sOdf
CD254
OPTB2
RANKL
TNLG6B
TRANCE
hRANKL2
Hide
Gene Full Name
TNF superfamily member 11
Gene Summary
This gene encodes a member of the tumor
necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin
and functions as a key factor for osteoclast differentiation and activation.
This protein was shown to be a dentritic cell survival factor and is involved
in the regulation of T cell-dependent immune response. T cell activation was
reported to induce expression of this gene and lead to an increase of
osteoclastogenesis and bone loss. This protein was shown to activate
antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase
and tumor necrosis factor receptor-associated factor (TRAF) 6, which
indicated this protein may have a role in the regulation of cell apoptosis.
Targeted disruption of the related gene in mice led to severe osteopetrosis
and a lack of osteoclasts. The deficient mice exhibited defects in early
differentiation of T and B lymphocytes, and failed to form lobulo-alveolar
mammary structures during pregnancy. Two alternatively spliced transcript
variants have been found. [provided by RefSeq, Jul 2008]
Hide
Molecular
Weight(MW)
35 KDa
Source
Rabbit
Cellular
Localizatio
Cytoplasm; Secreted and Cell membrane
Application
·
WB
Western blot
analysis using TNFSF11 antibody against MCF-7 (1) cell lysate.
·
IHC
Immunohistochemical
analysis of paraffin-embedded thyroid carcinoma tissues using TNFSF11 antibody
with DAB staining.
·
ICC/IF
Immunofluorescence
analysis of MCF-7 cells using TNFSF11 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-TNFSF11 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
TNFSF11
Gene Synonyms
TNF11
ODF
OPGL
sOdf
CD254
OPTB2
RANKL
TNLG6B
TRANCE
hRANKL2
Hide
Gene Full Name
TNF superfamily member 11
Gene Summary
This gene encodes a member of the tumor
necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin
and functions as a key factor for osteoclast differentiation and activation.
This protein was shown to be a dentritic cell survival factor and is involved
in the regulation of T cell-dependent immune response. T cell activation was
reported to induce expression of this gene and lead to an increase of
osteoclastogenesis and bone loss. This protein was shown to activate
antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase
and tumor necrosis factor receptor-associated factor (TRAF) 6, which
indicated this protein may have a role in the regulation of cell apoptosis.
Targeted disruption of the related gene in mice led to severe osteopetrosis
and a lack of osteoclasts. The deficient mice exhibited defects in early
differentiation of T and B lymphocytes, and failed to form lobulo-alveolar
mammary structures during pregnancy. Two alternatively spliced transcript
variants have been found. [provided by RefSeq, Jul 2008]
Hide
Molecular
Weight(MW)
35 KDa
Source
Rabbit
Cellular
Localizatio
Cytoplasm; Secreted and Cell membrane
Application
·
WB
Western blot
analysis using TNFSF11 antibody against MCF-7 (1) cell lysate.
·
IHC
Immunohistochemical
analysis of paraffin-embedded thyroid carcinoma tissues using TNFSF11 antibody
with DAB staining.
·
ICC/IF
Immunofluorescence
analysis of MCF-7 cells using TNFSF11 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-TNFSF11 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
TNFSF11
Gene Synonyms
TNF11
ODF
OPGL
sOdf
CD254
OPTB2
RANKL
TNLG6B
TRANCE
hRANKL2
Hide
Gene Full Name
TNF superfamily member 11
Gene Summary
This gene encodes a member of the tumor
necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin
and functions as a key factor for osteoclast differentiation and activation.
This protein was shown to be a dentritic cell survival factor and is involved
in the regulation of T cell-dependent immune response. T cell activation was
reported to induce expression of this gene and lead to an increase of
osteoclastogenesis and bone loss. This protein was shown to activate
antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase
and tumor necrosis factor receptor-associated factor (TRAF) 6, which
indicated this protein may have a role in the regulation of cell apoptosis.
Targeted disruption of the related gene in mice led to severe osteopetrosis
and a lack of osteoclasts. The deficient mice exhibited defects in early
differentiation of T and B lymphocytes, and failed to form lobulo-alveolar
mammary structures during pregnancy. Two alternatively spliced transcript
variants have been found. [provided by RefSeq, Jul 2008]
Hide
Molecular
Weight(MW)
35 KDa
Source
Rabbit
Cellular
Localizatio
Cytoplasm; Secreted and Cell membrane
Application
·
WB
Western blot
analysis using TNFSF11 antibody against MCF-7 (1) cell lysate.
·
IHC
Immunohistochemical
analysis of paraffin-embedded thyroid carcinoma tissues using TNFSF11 antibody
with DAB staining.
·
ICC/IF
Immunofluorescence
analysis of MCF-7 cells using TNFSF11 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-TNFSF11 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
TNFSF11
Gene Synonyms
TNF11
ODF
OPGL
sOdf
CD254
OPTB2
RANKL
TNLG6B
TRANCE
hRANKL2
Hide
Gene Full Name
TNF superfamily member 11
Gene Summary
This gene encodes a member of the tumor
necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin
and functions as a key factor for osteoclast differentiation and activation.
This protein was shown to be a dentritic cell survival factor and is involved
in the regulation of T cell-dependent immune response. T cell activation was
reported to induce expression of this gene and lead to an increase of
osteoclastogenesis and bone loss. This protein was shown to activate
antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase
and tumor necrosis factor receptor-associated factor (TRAF) 6, which
indicated this protein may have a role in the regulation of cell apoptosis.
Targeted disruption of the related gene in mice led to severe osteopetrosis
and a lack of osteoclasts. The deficient mice exhibited defects in early
differentiation of T and B lymphocytes, and failed to form lobulo-alveolar
mammary structures during pregnancy. Two alternatively spliced transcript
variants have been found. [provided by RefSeq, Jul 2008]
Hide
Molecular
Weight(MW)
35 KDa
Source
Rabbit
Cellular
Localizatio
Cytoplasm; Secreted and Cell membrane
Application
·
WB
Western blot
analysis using TNFSF11 antibody against MCF-7 (1) cell lysate.
·
IHC
Immunohistochemical
analysis of paraffin-embedded thyroid carcinoma tissues using TNFSF11 antibody
with DAB staining.
·
ICC/IF
Immunofluorescence
analysis of MCF-7 cells using TNFSF11 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-TNFSF11 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
TNFSF11
Gene Synonyms
TNF11
ODF
OPGL
sOdf
CD254
OPTB2
RANKL
TNLG6B
TRANCE
hRANKL2
Hide
Gene Full Name
TNF superfamily member 11
Gene Summary
This gene encodes a member of the tumor
necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin
and functions as a key factor for osteoclast differentiation and activation.
This protein was shown to be a dentritic cell survival factor and is involved
in the regulation of T cell-dependent immune response. T cell activation was
reported to induce expression of this gene and lead to an increase of
osteoclastogenesis and bone loss. This protein was shown to activate
antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase
and tumor necrosis factor receptor-associated factor (TRAF) 6, which
indicated this protein may have a role in the regulation of cell apoptosis.
Targeted disruption of the related gene in mice led to severe osteopetrosis
and a lack of osteoclasts. The deficient mice exhibited defects in early
differentiation of T and B lymphocytes, and failed to form lobulo-alveolar
mammary structures during pregnancy. Two alternatively spliced transcript
variants have been found. [provided by RefSeq, Jul 2008]
Hide
Molecular
Weight(MW)
35 KDa
Source
Rabbit
Cellular
Localizatio
Cytoplasm; Secreted and Cell membrane
Application
·
WB
Western blot
analysis using TNFSF11 antibody against MCF-7 (1) cell lysate.
·
IHC
Immunohistochemical
analysis of paraffin-embedded thyroid carcinoma tissues using TNFSF11 antibody
with DAB staining.
·
ICC/IF
Immunofluorescence
analysis of MCF-7 cells using TNFSF11 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-TNFSF11 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
TNFSF11
Gene Synonyms
TNF11
ODF
OPGL
sOdf
CD254
OPTB2
RANKL
TNLG6B
TRANCE
hRANKL2
Hide
Gene Full Name
TNF superfamily member 11
Gene Summary
This gene encodes a member of the tumor
necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin
and functions as a key factor for osteoclast differentiation and activation.
This protein was shown to be a dentritic cell survival factor and is involved
in the regulation of T cell-dependent immune response. T cell activation was
reported to induce expression of this gene and lead to an increase of
osteoclastogenesis and bone loss. This protein was shown to activate
antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase
and tumor necrosis factor receptor-associated factor (TRAF) 6, which
indicated this protein may have a role in the regulation of cell apoptosis.
Targeted disruption of the related gene in mice led to severe osteopetrosis
and a lack of osteoclasts. The deficient mice exhibited defects in early
differentiation of T and B lymphocytes, and failed to form lobulo-alveolar
mammary structures during pregnancy. Two alternatively spliced transcript
variants have been found. [provided by RefSeq, Jul 2008]
Hide
Molecular
Weight(MW)
35 KDa
Source
Rabbit
Cellular
Localizatio
Cytoplasm; Secreted and Cell membrane
Application
·
WB
Western blot
analysis using TNFSF11 antibody against MCF-7 (1) cell lysate.
·
IHC
Immunohistochemical
analysis of paraffin-embedded thyroid carcinoma tissues using TNFSF11 antibody
with DAB staining.
·
ICC/IF
Immunofluorescence
analysis of MCF-7 cells using TNFSF11 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-TNFSF11 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
TNFSF11
Gene Synonyms
TNF11
ODF
OPGL
sOdf
CD254
OPTB2
RANKL
TNLG6B
TRANCE
hRANKL2
Hide
Gene Full Name
TNF superfamily member 11
Gene Summary
This gene encodes a member of the tumor
necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin
and functions as a key factor for osteoclast differentiation and activation.
This protein was shown to be a dentritic cell survival factor and is involved
in the regulation of T cell-dependent immune response. T cell activation was
reported to induce expression of this gene and lead to an increase of
osteoclastogenesis and bone loss. This protein was shown to activate
antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase
and tumor necrosis factor receptor-associated factor (TRAF) 6, which
indicated this protein may have a role in the regulation of cell apoptosis.
Targeted disruption of the related gene in mice led to severe osteopetrosis
and a lack of osteoclasts. The deficient mice exhibited defects in early
differentiation of T and B lymphocytes, and failed to form lobulo-alveolar
mammary structures during pregnancy. Two alternatively spliced transcript
variants have been found. [provided by RefSeq, Jul 2008]
Hide
Molecular
Weight(MW)
35 KDa
Source
Rabbit
Cellular
Localizatio
Cytoplasm; Secreted and Cell membrane
Application
·
WB
Western blot
analysis using TNFSF11 antibody against MCF-7 (1) cell lysate.
·
IHC
Immunohistochemical
analysis of paraffin-embedded thyroid carcinoma tissues using TNFSF11 antibody
with DAB staining.
·
ICC/IF
Immunofluorescence
analysis of MCF-7 cells using TNFSF11 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
Product Profile
Product Name
Anti-TNFSF11 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
TNFSF11
Gene Synonyms
TNF11
Hide
Gene Full Name
TNF superfamily member 11
Gene Summary
This gene encodes a member of the tumor
necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin
and functions as a key factor for osteoclast differentiation and activation.
This protein was shown to be a dentritic cell survival factor and is involved
in the regulation of T cell-dependent immune response. T cell activation was
reported to induce expression of this gene and lead to an increase of
osteoclastogenesis and bone loss. This protein was shown to activate
antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase
and tumor necrosis factor receptor-associated factor (TRAF) 6, which
indicated this protein may have a role in the regulation of cell apoptosis.
Targeted disruption of the related gene in mice led to severe osteopetrosis
and a lack of osteoclasts. The deficient mice exhibited defects in early
differentiation of T and B lymphocytes, and failed to form lobulo-alveolar
mammary structures during pregnancy. Two alternatively spliced transcript
variants have been found. [provided by RefSeq, Jul 2008]
Hide
Molecular
Weight(MW)
35 KDa
Source
Rabbit
Cellular
Localizatio
Cytoplasm; Secreted and Cell membrane
Application
·
WB
Western blot
analysis using TNFSF11 antibody against MCF-7 (1) cell lysate.
·
IHC
Immunohistochemical
analysis of paraffin-embedded thyroid carcinoma tissues using TNFSF11 antibody
with DAB staining.
·
ICC/IF
Immunofluorescence
analysis of MCF-7 cells using TNFSF11 antibody (green). Blue: DAPI fluorescent
DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555
phalloidin.
Application
Notes
WB:1:200-1:2000
Additional Information
Form
Liquid
Storage
Instruction
Shipped at 4°C. Store at +4°C short term
(1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05%
sodium azide.
IHC:1:200-1:1000
ICC/IF:1:100-1:500
ODF
OPGL
sOdf
CD254
OPTB2
RANKL
TNLG6B
TRANCE
hRANKL2
IHC:1:200-1:1000
ICC/IF:1:100-1:500
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