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产地 | 上海 |
品牌 | OminimAbs |
保存条件 | |
货号 | OM641708 |
用途 | 实验研究 |
应用范围 | 科研实验 |
抗原来源 | 电询 |
保质期 | 2年 |
抗体名 | 电询 |
是否单克隆 | 否 |
克隆性 | 否 |
靶点 | 电询 |
适应物种 | 电询 |
形态 | 电询 |
宿主 | 电询 |
标记物 | 电询 |
包装规格 | 毫升 |
亚型 | 电询 |
标识物 | 电询 |
浓度 | 电询% |
免疫原 | 电询 |
是否进口 | 否 |
Product Profile
Product Name
Anti-PMS-2 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFWB
WB:1:200-1:2000
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
PMS2
Gene Synonyms
MLH4
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Gene Full Name
PMS1 homolog 2, mismatch repair system
component
Gene Summary
The protein encoded by this gene is a key
component of the mismatch repair system that functions to correct DNA
mismatches and small insertions and deletions that can occur during DNA
replication and homologous recombination. This protein forms heterodimers
with the gene product of the mutL homolog 1 (MLH1) gene to form the
MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an
endonucleolytic activity that is activated following recognition of
mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta
heterodimers, and is necessary for removal of the mismatched DNA. There is a
DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by this
gene that forms part of the active site of the nuclease. Mutations in this
gene have been associated with hereditary nonpolyposis colorectal cancer
(HNPCC; also known as Lynch syndrome) and Turcot syndrome. [provided by
RefSeq, Apr 2016]
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Molecular
Weight(MW)
96 KDa
Source
Rabbit
Cellular
Localizatio
Nucleus
Application
ICC/IF:1:100-1:500
PMSL2
HNPCC4
MMRCS4
PMS2CL
·
WB
Western blot analysis using PMS-2 antibody against HUVEC (1), PANC-1 (2), MCF-7 (3) HepG2 (4) cell lysate.
·
ICC/IF
Immunofluorescence analysis of MG-63 cells using PMS-2 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application Notes |
WB:1:200-1:2000 |
Additional Information
Form |
Liquid |
Storage Instruction |
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
Storage Buffer |
Purified antibody in PBS with 0.05% sodium azide. |