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产地 | 上海 |
品牌 | OminimAbs |
保存条件 | |
货号 | 电询 |
用途 | 实验研究 |
应用范围 | 科研实验 |
抗原来源 | 电询 |
保质期 | 2年 |
抗体名 | 电询 |
是否单克隆 | |
克隆性 | 否 |
靶点 | 电询 |
适应物种 | 电询 |
形态 | 电询 |
宿主 | 电询 |
标记物 | 电询 |
包装规格 | 毫升 |
亚型 | 电询 |
标识物 | 电询 |
浓度 | 电询% |
免疫原 | 电询 |
是否进口 | 否 |
Product Profile
Product Name
Anti-CASP1 antibody
Antibody Type
Primary Antibodies
Immunogen
Polypeptide
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested
Application
ELISAICC/IFIHCWB
WB:1:200-1:2000
Species
Reactivity
HumanMouseRat
Concentration
1 mg/ml
Purification
Protein A
Target Information
Gene Symbol
CASP1
Gene Synonyms
ICE
Gene Full Name
caspase 1
Gene Summary
This gene encodes a protein which is a
member of the cysteine-aspartic acid protease (caspase) family. Sequential
activation of caspases plays a central role in the execution-phase of cell
apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic
processing at conserved aspartic residues to produce 2 subunits, large and
small, that dimerize to form the active enzyme. This gene was identified by
its ability to proteolytically cleave and activate the inactive precursor of
interleukin-1, a cytokine involved in the processes such as inflammation,
septic shock, and wound healing. This gene has been shown to induce cell
apoptosis and may function in various developmental stages. Studies of a
similar gene in mouse suggest a role in the pathogenesis of Huntington
disease. Alternative splicing results in transcript variants encoding
distinct isoforms. [provided by RefSeq, Mar 2012]
Hide
Molecular
Weight(MW)
45 KDa
Source
Rabbit
Cellular
Localizatio
Cell membrane, Cytoplasm, Membrane
Application
IHC:1:200-1:1000
ICC/IF:1:100-1:500
P45
IL1BC
·
WB
Western blot analysis using CASP1 antibody against HEK293 (1), HepG2 (2) cell lysate.
·
IHC
Immunohistochemical analysis of paraffin-embedded renal carcinoma tissues using CASP1 antibody with DAB staining.
·
ICC/IF
Immunofluorescence analysis of NIH/3T3 cells using CASP1 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application Notes |
WB:1:200-1:2000 |
Additional Information
Form |
Liquid |
Storage Instruction |
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
Storage Buffer |
Purified antibody in PBS with 0.05% sodium azide. |