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产地 | 上海 |
品牌 | OminimAbs |
保存条件 | |
货号 | OM641708 |
用途 | 实验研究 |
应用范围 | 科研实验 |
抗原来源 | 电询 |
保质期 | 2年 |
抗体名 | 电询 |
是否单克隆 | 否 |
克隆性 | 否 |
靶点 | 电询 |
适应物种 | 电询 |
形态 | 电询 |
宿主 | 电询 |
标记物 | 电询 |
包装规格 | 毫升 |
亚型 | 电询 |
标识物 | 电询 |
浓度 | 电询% |
免疫原 | 电询 |
是否进口 | 否 |
Product Profile
Product Name |
Anti-Smad2 antibody |
Antibody Type |
Primary Antibodies |
Immunogen |
Polypeptide |
Key Feature
Clonality |
Polyclonal |
Isotype |
IgG |
Host Species |
Rabbit |
Tested Application |
ELISAICC/IFIHC |
IHC:1:200-1:1000 |
|
Species Reactivity |
HumanMouseRat |
Concentration |
1 mg/ml |
Purification |
Protein A |
Target Information
Gene Symbol |
SMAD2 |
Gene Synonyms |
JV18 More |
Gene Full Name |
SMAD family member 2 |
Gene Summary |
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012] More |
Source |
Rabbit |
Cellular Localizatio |
Cytoplasm. Nucleus. |
Application
·
IHC
Immunohistochemical analysis of paraffin-embedded lung cancer tissues using Smad2 antibody with DAB staining.
·
ICC/IF
Immunofluorescence analysis of SK-OV-3 cells using Smad2 antibody(green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Application Notes |
IHC:1:200-1:1000 |
Additional Information
Form |
Liquid |
Storage Instruction |
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
Storage Buffer |
Purified antibody in PBS with 0.05% sodium azide. |