Product Name

Anti-RUNX1+RUNX2+RUNX3 antibody

Antibody Type

Primary Antibodies

Immunogen

Polypeptide

Clonality

Polyclonal

Isotype

IgG

Host Species

Rabbit

Tested Application

ELISAIHCWB

WB:1:200-1:2000
IHC:1:200-1:1000

Species Reactivity

HumanMouseRat

Concentration

1 mg/ml

Purification

Protein A

Gene Symbol

RUNX1+RUNX2+RUNX3

Gene Synonyms

CCD
AML3
CCD1
CLCD
OSF2
CBFA1
OSF-2
PEA2aA
PEBP2aA
CBF-alpha-1

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Gene Full Name

RUNX family transcription factor 2

Gene Summary

This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Jul 2016]

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Molecular Weight(MW)

49 kDa

Source

Rabbit

Cellular Localizatio

Nucleus; Cytoplasm

Application Notes

WB:1:200-1:2000
IHC:1:200-1:1000

Form

Liquid

Storage Instruction

Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.

Storage Buffer

Purified antibody in PBS with 0.05% sodium azi.