Product Name

Anti-Caspase 9 antibody

Antibody Type

Primary Antibodies

Immunogen

Polypeptide

Clonality

Polyclonal

Isotype

IgG

Host Species

Rabbit

Tested Application

ELISAICC/IFIHCWB

WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500

Species Reactivity

HumanMouseRat

Concentration

1 mg/ml

Purification

Protein A

Gene Symbol

CASP 9

Gene Synonyms

MCH6
APAF3
APAF-3
PPP1R56
ICE-LAP6

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Gene Full Name

caspase 9

Gene Summary

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

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Molecular Weight(MW)

46 kDa

Source

Rabbit

Cellular Localizatio

Cytosol;Mitochondrion;Nucleus

Application Notes

WB:1:200-1:2000
IHC:1:200-1:1000
ICC/IF:1:100-1:500

Form

Liquid

Storage Instruction

Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.

Storage Buffer

Purified antibody in PBS with 0.05% sodium azi.