Product Name

Anti-Cyclin D1 antibody

Antibody Type

Primary Antibodies

Immunogen

Polypeptide

Clonality

Polyclonal

Isotype

IgG

Host Species

Rabbit

Tested Application

ELISAIHCWB

IHC:1:50~1:200
WB:1:500~1:2000
Notes:Optimal dilutions/concentrations should be determined by the researcher.

Species Reactivity

HumanMouseRat

Concentration

1 mg/ml

Purification

Protein A

Gene Symbol

CCND1

Gene Synonyms

BCL1
PRAD1
U21B31
D11S287E

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Gene Full Name

cyclin D1

Gene Summary

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of human cancers. [provided by RefSeq, Dec 2019]

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Molecular Weight(MW)

34 kDa（Observed: 40 kDa）

Cellular Localizatio

Nucleus

Application Notes

IHC:1:50~1:200
WB:1:500~1:2000
Notes:Optimal dilutions/concentrations should be determined by the researcher.

Form

Liquid

Storage Instruction

Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.

Storage Buffer

Purified antibody in PBS with 0.05% sodium azide.