推荐：2-氯-2,2-二氟本乙酮 95%@2024已更新

别名:2-Chloro-2,2-difluoro-1-phenylethanone, Chlorodifluoromethyl phenyl ketone, α-Chloro-α,α-difluoroacetophenone

线性分子式:C6H5COCF2Cl

CAS号:384-67-8

分子量:190.57

Beilstein:2251448

MDL编号:MFCD00042123

PubChem化学物质编号:329768330

属性
质量水平
100

检测方案
95%

形式
liquid

reaction suitability
reaction type: C-C Bond Formation

折射率
n20/D 1.4954
n20/D 1.497 (lit.)

bp
94-96 °C/35 mmHg (lit.)

密度
1.293 g/mL at 25 °C (lit.)
1.3178 g/mL at 25 °C

SMILES string
FC(F)(Cl)C(=O)c1ccccc1

InChI
1S/C8H5ClF2O/c9-8(10,11)7(12)6-4-2-1-3-5-6/h1-5H

InChI key
MNOONJNILVDLSW-UHFFFAOYSA-N

说明
一般描述
2-Chloro-2,2-difluoroacetophenone is a difluorocarbene reagent, which is generally used in the synthesis of 2,2-difluoro enol silyl ethers, and gem -difluoromethene derived compounds.[1]
应用
2-Chloro-2,2-difluoroacetophenone can be used:
As a reagent in the difluoromethylation of various phenols to yield aryl difluoromethyl ethers.[2]
As a precursor in the Baylis-Hillman reaction of fluoroalkyl ketones to obtain chlorodifluoromethyl containing products.[3]
As a substrate in the synthesis of propargyl alcohols using a novel ruthenium catalyst.[4]

Reagent is an effective product for the synthesis of difluoromethylated phenols in the presence of mild base and aqueous solvent.

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发表刊物        影响因子           奖励金额
SCI期刊杂志      1.0≤1F＜3.0          200元
SCI期刊杂志      3.0≤1F＜6.0          400元
SCI期刊杂志      6.0≤1F＜10.0         600元
SCI期刊杂志      1F≥10                1000元